Skip to main content
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1982 Jul;58(681):443–444. doi: 10.1136/pgmj.58.681.443

Reversible agranulocytosis in association with cimetidine and hepatic failure

D S Lewis, E R Beck
PMCID: PMC2426507  PMID: 7122393

Abstract

A patient is described who developed agranulocytosis in the context of hepatic failure and cimetidine therapy. The close temporal relationship between discontinuation of the drug and granulopoietic recovery is considered to imply a role for cimetidine in the mechanism of the agranulocytosis.

Full text

PDF
443

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Burland W. L., Duncan W. A., Hesselbo T., Mills J. G., Sharpe P. C., Haggie S. J., Wyllie J. H. Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man. Br J Clin Pharmacol. 1975 Dec;2(6):481–486. doi: 10.1111/j.1365-2125.1975.tb00564.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Dupont T., Beaugrand M., Brunet J. M., Azouz-Abdallah M., Baylocq D., Champault G., Ferrier J. P. Etude des concentrations plasmatiques de cimétidine chez des malades cirrhotiques et non cirrhotiques atteints d'hémorragie digestive. Gastroenterol Clin Biol. 1981 Feb;5(2):155–160. [PubMed] [Google Scholar]
  3. Freston J. W. Cimetidine and granulocytopenia. Ann Intern Med. 1979 Feb;90(2):264–265. doi: 10.7326/0003-4819-90-2-264. [DOI] [PubMed] [Google Scholar]
  4. Klotz S. A., Kay B. F. Cimetidine and Agranulocytosis. Ann Intern Med. 1978 Apr;88(4):579–580. doi: 10.7326/0003-4819-88-4-579_2. [DOI] [PubMed] [Google Scholar]
  5. Sonne J., Poulsen H. E., Døssing M., Larsen N. E., Andreasen P. B. Cimetidine clearance and bioavailability in hepatic cirrhosis. Clin Pharmacol Ther. 1981 Feb;29(2):191–197. doi: 10.1038/clpt.1981.30. [DOI] [PubMed] [Google Scholar]
  6. Ufberg M. H., Brooks C. M., Bosanac P. R., Kintzel J. E. Transient neutropenia in a patient receiving cimetidine. Gastroenterology. 1977 Sep;73(3):635–638. [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES