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. 1982 Nov;58(685):680–684. doi: 10.1136/pgmj.58.685.680

Thyroid disease in diabetics.

D D Sugrue, M McEvoy, M I Drury
PMCID: PMC2426579  PMID: 7170265

Abstract

Among a diabetic clinic population of 5,000 there were 113 patients (1.1%) with concurrent clinical thyroid dysfunction (56 hyperthyroid, 57 hypothyroid). Seventy-one (62.8%) of these patients were insulin-dependent and diabetes preceded thyroid disease in 85 (75.2%). Twenty patients were given carbimazole for two or more years and of these 15 (75%) relapsed, a percentage not significantly different from that seen in non-diabetic patients. The value of screening diabetic patients for evidence of thyroid dysfunction is discussed.

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Selected References

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  1. ANTILA V., KUUSISTO A. N. Has the new antidiabetic drug, N1-sulphanilyl-N2-N-butylcarbamide goitrogenic properties? An experimental study. Acta Endocrinol (Copenh) 1956 Dec;23(4):433–436. doi: 10.1530/acta.0.0230433. [DOI] [PubMed] [Google Scholar]
  2. BARON D. N. Hypothyroidism and diabetes mellitus. Lancet. 1955 Oct 15;269(6894):796–798. doi: 10.1016/s0140-6736(55)92387-4. [DOI] [PubMed] [Google Scholar]
  3. BOWEN B. D., LENZNER A. R. The use of propylthiouracil in hyperthyroidism and diabetes; a study of 41 cases. N Engl J Med. 1951 Oct 25;245(17):629–633. doi: 10.1056/NEJM195110252451701. [DOI] [PubMed] [Google Scholar]
  4. BRESLAW L., LASHOF J., KLEIN C. Diabetes mellitus, hyperthyroidism and Addison's disease in one patient. Ann Intern Med. 1953 Feb;38(2):338–342. doi: 10.7326/0003-4819-38-2-338. [DOI] [PubMed] [Google Scholar]
  5. Bottazzo G. F., Cudworth A. G., Moul D. J., Doniach D., Festenstein H. Evidence for a primary autoimmune type of diabetes mellitus. Br Med J. 1978 Nov 4;2(6147):1253–1255. doi: 10.1136/bmj.2.6147.1253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bottazzo G. F., Florin-Christensen A., Doniach D. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet. 1974 Nov 30;2(7892):1279–1283. doi: 10.1016/s0140-6736(74)90140-8. [DOI] [PubMed] [Google Scholar]
  7. Bottazzo G. F., Mann J. I., Thorogood M., Baum J. D., Doniach D. Autoimmunity in juvenile diabetics and their families. Br Med J. 1978 Jul 15;2(6131):165–168. doi: 10.1136/bmj.2.6131.165. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Bridgman J. F. Diabetes mellitus and hypothyroidism. Postgrad Med J. 1971 Dec;47(554):781–784. doi: 10.1136/pgmj.47.554.781. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Evered D., Hall R. Hypothyroidism. Br Med J. 1972 Jan 29;1(5795):290–293. doi: 10.1136/bmj.1.5795.290. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. FARRER-BROWN G. Myxoedema followed by Addison's disease and diabetes mellitus. Postgrad Med J. 1962 Aug;38:473–475. doi: 10.1136/pgmj.38.442.473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Feely J., Isles T. E. Screening for thyroid dysfunction in diabetics. Br Med J. 1979 Jun 23;1(6179):1678–1678. doi: 10.1136/bmj.1.6179.1678. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Ganz K., Kozak G. P. Diabetes mellitus and primary hypothyroidism. Arch Intern Med. 1974 Sep;134(3):430–432. [PubMed] [Google Scholar]
  13. Gershberg H., Hecht A. Normal blood calcium homeostasis in response to calcium infusion in pseudohypoparathyroidism and idiopathic hypoparathyroidism. Proc Soc Exp Biol Med. 1968 May;128(1):9–11. doi: 10.3181/00379727-128-32930. [DOI] [PubMed] [Google Scholar]
  14. Goldstein D. E., Drash A., Gibbs J., Blizzard R. M. Diabetes mellitus: the incidence of circulating antibodies against thyroid, gastric, and adrenal tissue. J Pediatr. 1970 Aug;77(2):304–306. doi: 10.1016/s0022-3476(70)80342-0. [DOI] [PubMed] [Google Scholar]
  15. HUNTON R. B., WELLS M. V., SKIPPER E. W. HYPOTHYROIDISM IN DIABETICS TREATED WITH SULPHONYLUREA. Lancet. 1965 Sep 4;2(7410):449–451. doi: 10.1016/s0140-6736(65)91418-2. [DOI] [PubMed] [Google Scholar]
  16. Hecht A., Gershberg H. Diabetes mellitus and primary hypothyroidism. Metabolism. 1968 Feb;17(2):108–113. doi: 10.1016/0026-0495(68)90136-4. [DOI] [PubMed] [Google Scholar]
  17. Howard C. P., Hayles A. B. Hyperthyroidism in childhood. Clin Endocrinol Metab. 1978 Mar;7(1):127–143. doi: 10.1016/s0300-595x(78)80039-5. [DOI] [PubMed] [Google Scholar]
  18. Irvine W. J., Clarke B. F., Scarth L., Cullen D. R., Duncan L. J. Thyroid and gastric autoimmunity in patients with diabetes mellitus. Lancet. 1970 Jul 25;2(7665):163–168. doi: 10.1016/s0140-6736(70)92531-6. [DOI] [PubMed] [Google Scholar]
  19. LANDING B. H., PETTIT M. D., WIENS R. L., KNOWLES H., GUEST G. M. Antithyroid antibody and chronic thyroiditis in diabetes. J Clin Endocrinol Metab. 1963 Jan;23:119–120. doi: 10.1210/jcem-23-1-119. [DOI] [PubMed] [Google Scholar]
  20. LAZARUS S. S., VOLK B. W. The estimation of insulin sensitivity by the modified glucose insulin tolerance test. J Lab Clin Med. 1952 Mar;39(3):404–413. [PubMed] [Google Scholar]
  21. McKenna R., Kearns M., Sugrue D., Drury M. I., McCarthy C. F. HLA and hyperthyroidism in Ireland. Tissue Antigens. 1982 Feb;19(2):97–99. doi: 10.1111/j.1399-0039.1982.tb01423.x. [DOI] [PubMed] [Google Scholar]
  22. Medalie J. H., Papier C. M., Goldbourt U., Herman J. B. Major factors in the development of diabetes mellitus in 10,000 men. Arch Intern Med. 1975 Jun;135(6):811–817. [PubMed] [Google Scholar]
  23. Okajima F., Ui M. Adrenergic modulation of insulin secretion in vivo dependent on thyroid states. Am J Physiol. 1978 Feb;234(2):E106–E111. doi: 10.1152/ajpendo.1978.234.2.E106. [DOI] [PubMed] [Google Scholar]
  24. Okajima F., Ui M. Metabolism of glucose in hyper- and hypo-thyroid rats in vivo. Glucose-turnover values and futile-cycle activities obtained with 14C- and 3H-labelled glucose. Biochem J. 1979 Aug 15;182(2):565–575. doi: 10.1042/bj1820565. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. PETTIT M. D., LANDING B. H., GUEST G. M. Antithyroid antibody in juvenile diabetics. J Clin Endocrinol Metab. 1961 Feb;21:209–210. doi: 10.1210/jcem-21-2-209. [DOI] [PubMed] [Google Scholar]
  26. Palumbo P. J., Labarthe D. R. The incidence of diabetes mellitus in Rochester Minnesota, 1945-1969. Adv Metab Disord. 1978;9:13–28. doi: 10.1016/b978-0-12-027309-6.50007-0. [DOI] [PubMed] [Google Scholar]
  27. Prince R. L., Worth G. K., Shenfield G. M. Sulphonylurea therapy and hypothyroidism. Practitioner. 1980 Dec;224(1350):1287–1289. [PubMed] [Google Scholar]
  28. RALLI E. P., STREET E., PELL S. The course and complications of diabetes mellitus; data in 331 cases observed regularly in a diabetic clinic. Diabetes. 1955 Nov-Dec;4(6):456–464. doi: 10.2337/diab.4.6.456. [DOI] [PubMed] [Google Scholar]
  29. SOLOMON D. H., BECK J. C., VANDERLAAN W. P. Prognosis of hyperthyroidism treated by antithyroid drugs. J Am Med Assoc. 1953 May 16;152(3):201–205. doi: 10.1001/jama.1953.03690030001001. [DOI] [PubMed] [Google Scholar]
  30. Saunders J., Hall S. E., Sönksen P. H. Thyroid hormones in insulin requiring diabetes before and after treatment. Diabetologia. 1978 Jul;15(1):29–32. doi: 10.1007/BF01219324. [DOI] [PubMed] [Google Scholar]
  31. Sugrue D., McEvoy M., Feely J., Drury M. I. Hyperthyroidism in the land of Graves: results of treatment by surgery, radio-iodine and carbimazole in 837 cases. Q J Med. 1980 Winter;49(193):51–61. [PubMed] [Google Scholar]
  32. Tunbridge W. M., Brewis M., French J. M., Appleton D., Bird T., Clark F., Evered D. C., Evans J. G., Hall R., Smith P. Natural history of autoimmune thyroiditis. Br Med J (Clin Res Ed) 1981 Jan 24;282(6260):258–262. doi: 10.1136/bmj.282.6260.258. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Tunbridge W. M., Evered D. C., Hall R., Appleton D., Brewis M., Clark F., Evans J. G., Young E., Bird T., Smith P. A. The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf) 1977 Dec;7(6):481–493. doi: 10.1111/j.1365-2265.1977.tb01340.x. [DOI] [PubMed] [Google Scholar]
  34. Tunbridge W. M. The epidemiology of hypothyroidism. Clin Endocrinol Metab. 1979 Mar;8(1):21–27. doi: 10.1016/s0300-595x(79)80006-7. [DOI] [PubMed] [Google Scholar]
  35. Whittingham S., Mathews J. D., Mackay I. R., Stocks A. E., Ungar B., Martin F. I. Diabetes mellitus, autoimmunity, and ageing. Lancet. 1971 Apr 17;1(7703):763–766. doi: 10.1016/s0140-6736(71)91212-8. [DOI] [PubMed] [Google Scholar]

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