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. 1990 May;66(775):392–394. doi: 10.1136/pgmj.66.775.392

Severe haemolytic anaemia due to cold anti-'i' antibodies associated with cytomegalovirus infection.

J M Aguado 1, J M Castrillo 1, J Sanz 1, J Serrano 1
PMCID: PMC2426850  PMID: 2164663

Abstract

A 66 year old patient with multiple myeloma and monoclonal cryoglobulinaemia who developed a severe haemolytic anaemia following a cytomegalovirus infection is reported. The presence of a high titre of anti-'i' cold antibody of IgM subclass is demonstrated. Anti-'i' antibody disappeared when complement-fixation antibody titres against cytomegalovirus decreased. Various pathogenetic mechanisms involved in the development of haemolytic anaemia associated with cytomegalovirus infection are discussed. To our knowledge, this is the first case described in the English language publications associating severe haemolytic anaemia with an anti-'i' antibody after a cytomegalovirus infection in an immunocompromised patient.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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