Table 1.
Demographics and clinical variables
| Parameter | nsLD | ALC | HD | nsALC | sALC | nsHD | sHD |
|---|---|---|---|---|---|---|---|
| Number of participants (females) | 38 (8) | 35 (2) | 32 (5) | 15 (0) | 20 (2) | 18 (4) | 14 (1) |
| Age [years] | 45.4 ± 8.1 | 45.9 ± 8.3 | 42.4 ± 8.9 | 47.9 ± 8.1 | 44.4 ± 8.4 | 42.7 ± 9.9 | 42.0 ± 7.8 |
| Education [years] | 15.8 ± 2.2**$$ | 14.0 ± 2.1** | 14.4 ± 2.1$$ | 13.9 ± 2.3 | 14.1 ± 2.0 | 15.1 ± 2.1 | 13.6 ± 1.7 |
| AMNART | 119.9 ± 8.4 | 110.8 ± 9.2 | 114.0 ± 8.4 | 109.5 ± 10.3 | 111.8 ± 8.5 | 117.1 ± 6.1 | 110.5 ± 9.4 |
| Family History Density | 0.24 ± 0.31** | 0.83 ± 0.49**## | 0.38 ± 0.41## | 0.81 ± 0.40 | 0.85 ± 0.56 | 0.35 ± 0.35 | 0.42 ± 0.48 |
| Beck Depression Inventory | 6.0 ± 5.7 | 7.9 ± 7.7 | 9.1 ± 8.4 | 5.1 ± 5.5 | 10.1 ± 8.5 | 8.1 ± 7.3 | 10.3 ± 9.7 |
| 1-yr average [drinks/month] | 12 ± 17 | 385 ± 191## | 217 ± 135## | 403 ± 207 | 372 ± 183 | 205 ± 130 | 233 ± 144 |
| 3-yr average [dri/month] | 12 ± 17 | 369 ± 171## | 226 ± 121## | 385 ± 180 | 357 ± 168 | 213 ± 123 | 242 ± 121 |
| Lifetime average [dri/month] | 15 ± 14 | 218 ± 109 | 186 ± 146 | 193 ± 119 | 236 ± 100 | 147 ± 87 | 236 ± 191 |
| Lifetime years | 28.2 ± 5.7 | 29.3 ± 9.3## | 25.5 ± 9.5## | 31.6 ± 9.3 | 27.6 ± 9.2 | 25.5 ± 10.8 | 25.6 ± 7.9 |
| Total lifetime consumption [kg] | 65 ± 63 | 1035 ± 664## | 792 ± 837## | 989 ± 751 | 1069 ± 609 | 566 ± 417 | 1081 ± 302 |
| Onset of heavy drinking [years] | - | 23.6 ± 9.0 | 23.4 ± 8.4 | 26.1 ± 10.3 | 21.8 ± 7.6 | 25.7 ± 9.3 | 20.5 ± 6.2 |
| Months of heavy drinking | - | 231 ± 107# | 174 ± 110# | 222 ± 102 | 238 ± 113 | 143 ± 116 | 213 ± 91 |
| Age at first drink [years] | 18.2 ± 3.6 | 16.6 ± 3.2 | 16.6 ± 3.4 | 16.3 ± 3.3 | 16.8 ± 3.2 | 16.9 ± 2.6 | 16.4 ± 4.3 |
| Intracranial Volume [cc] | 1498 ± 137 | 1513 ± 124 | 1472 ± 150 | 1501 ± 104 | 1522 ± 139 | 1468 ± 171 | 1478 ± 124 |
| Hep-C [n] | 0 | 4 | 0 | 2 | 2 | 0 | 0 |
| Hypertension [n] | 0 | 7 | 0 | 2 | 5 | 0 | 0 |
| Unipolar mood disorders | 0 | 13 | 3 | 5 | 8 | 1 | 2 |
AMNART = American National Adult Reading Test; 1-yr average = number of drinks per month over 1-year prior to study; 3 yr average = number of drinks per month over 3- years prior to study; Lifetime average = number of drinks per month over lifetime; Lifetime years = number of years of regular alcohol consumption over lifetime. Total lifetime consumption = total amount of pure EtOH (kg) consumed over lifetime. Onset of heavy drinking = age when alcohol consumption exceeded 100 drinks per month
#
contrast between ALC and HD;
*
contrast between ALC and nsLD;
$
contrast between HD and nsLD; for all contrasts: one symbol p < 0.05; two symbols p < 0.01.