Abstract
The minimum emetic dose of deoxynivalenol to swine weighing 9 to 10 kg was 0.05 mg/kg of body weight intraperitoneally and 0.1 to 0.2 mg/kg orally. There was no emesis by undosed pigs consuming vomitus from pigs orally dosed with deoxynivalenol or penned with such pigs without access to vomitus. Analysis by gas-liquid chromatography of a sample of Gibberella zeae-infected corn containing about 25% visually damaged kernels indicated 12 ppm of deoxynivalenol. Deoxynivalenol added to feed reduced feed consumption of 20- to 45-kg pigs, ranging from a 20% decrease with 3.6 ppm to 90% reduction with 40 ppm. Loss in weight was associated with feed refusal. Feed refusal, however, was much greater for naturally infected corn samples than for feeds with equal concentrations of the pure compound added, indicating the involvement of an additional factor(s) in the swine refusal response.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Caldwell R. W., Tuite J., Stob M., Baldwin R. Zearalenone production by Fusarium species. Appl Microbiol. 1970 Jul;20(1):31–34. doi: 10.1128/am.20.1.31-34.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Featherston W. R. Utilization of gibberella-infected corn by chicks and rats. Poult Sci. 1973 Nov;52(6):2334–2335. doi: 10.3382/ps.0522334. [DOI] [PubMed] [Google Scholar]
- Ishii K., Ando Y., Ueno Y. Toxicological approaches to the metabolites of Fusaria. IX. Isolation of vomiting factor from moldy corn infected with Fusarium species. Chem Pharm Bull (Tokyo) 1975 Sep;23(9):2162–2164. doi: 10.1248/cpb.23.2162. [DOI] [PubMed] [Google Scholar]
- Kotsonis F. N., Smalley E. B., Ellison R. A., Gale C. M. Feed refusal factors in pure cultures of Fusarium roseum 'graminearum'. Appl Microbiol. 1975 Sep;30(3):362–368. doi: 10.1128/am.30.3.362-368.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mirocha C. J., Pathre S. V., Schauerhamer B., Christensen C. M. Natural occurrence of Fusarium toxins in feedstuff. Appl Environ Microbiol. 1976 Oct;32(4):553–556. doi: 10.1128/aem.32.4.553-556.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ueno Y., Ishii K., Sato N., Otsubo K. Toxicological approaches to the metabolites of Fusaria. VI. Vomiting factor from moldy corn infected with Fusarium spp. Jpn J Exp Med. 1974 Feb;44(1):123–127. [PubMed] [Google Scholar]
- Vesonder R. F., Ciegler A., Jensen A. H. Isolation of the emetic principle from Fusarium-infected corn. Appl Microbiol. 1973 Dec;26(6):1008–1010. doi: 10.1128/am.26.6.1008-1010.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vesonder R. F., Ciegler A., Jensen A. H., Rohwedder W. K., Weisleder D. Co-identity of the refusal and emetic principle from Fusarium-infected corn. Appl Environ Microbiol. 1976 Feb;31(2):280–285. doi: 10.1128/aem.31.2.280-285.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]