Abstract
The mouse toxin-neutralization test procedure described has been used for antitoxin titration of sera of New Guinea women following primary immunization with plain and adjuvant tetanus toxoids and following booster immunization, and for titration of guinea-pig sera.
The responses of guinea-pigs immunized with the same toxoids and immunization schedule to simulate the human field trial studies were observed for 6 months. The relative antitoxin responses of guinea-pigs to the different toxoids were similar to those of the women.
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Selected References
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- HORNIBROOK J. W. The avidity of test toxins in relationship to tetanus antitoxin titrations. J Lab Clin Med. 1952 Jul;40(1):58–66. [PubMed] [Google Scholar]
- Hardegree M. C., Barile M. F., Pittman M., Schofield F. D., Maclennan R., Kelly A. Immunization against neonatal tetanus in New Guinea. Bull World Health Organ. 1970;43(3):439–451. [PMC free article] [PubMed] [Google Scholar]
- IPSEN J. Changes in immunity and antitoxin level immediately after secondary stimulus with tetanus toxoid in rabbits. J Immunol. 1961 Jan;86:50–55. [PubMed] [Google Scholar]
- IPSEN J., Jr Immunization of adults against diphtheria and tetanus. N Engl J Med. 1954 Sep 16;251(12):459–466. doi: 10.1056/NEJM195409162511202. [DOI] [PubMed] [Google Scholar]
- MacLennan R., Schofield F. D., Pittman M., Hardegree M. C., Barile M. F. Immunization against neonatal tetanus in New Guinea. Antitoxin response of pregnant women to adjuvant and plain toxoids. Bull World Health Organ. 1965;32(5):683–697. [PMC free article] [PubMed] [Google Scholar]
- Pittman M., Kolb R. W., Barile M. F., Hardegree M. C., Seligmann E. B., Jr, Maclennan R., Schofield F. D. Immunization against neonatal tetanus in New Guinea. 5. Laboratory assayed potency of tetanus toxoids and relationship to human antitoxin response. Bull World Health Organ. 1970;43(3):469–478. [PMC free article] [PubMed] [Google Scholar]