Skip to main content
Bulletin of the World Health Organization logoLink to Bulletin of the World Health Organization
. 1969;41(3-4-5):549–551.

Antibody responses to and efficacy of an inactivated spray vaccine

A S Beare, D Hobson, Sylvia E Reed, D A J Tyrrell
PMCID: PMC2427692  PMID: 5309470

Abstract

An attempt was made to assess the protective influence of killed intranasal influenza B vaccine against a homologous virus challenge. Two types of trial were performed. In the first of these, the vaccine was compared with an inert placebo and, in the second, with conventional homologous and heterologous parenteral vaccines. Little protective effect by the intranasal vaccine was demonstrated.

Full text

PDF
549

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beare A. S., Bynoe M. L., Tyrrell D. A. Investigetion into the attenuation of influenza viruses by serial passage. Br Med J. 1968 Nov 23;4(5629):482–484. doi: 10.1136/bmj.4.5629.482. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beare A. S., Hobson D., Reed S. E., Tyrrell D. A. A comparison of live and killed influenza-virus vaccines. Report to the Medical Research Council's Committee on Influenza and other Respiratory Virus Vaccines. Lancet. 1968 Aug 24;2(7565):418–422. doi: 10.1016/s0140-6736(68)90463-7. [DOI] [PubMed] [Google Scholar]
  3. Kasel J. A., Hume E. B., Fulk R. V., Togo Y., Huber M., Hornick R. B. Antibody responses in nasal secretions and serum of elderly persons following local or parenteral administration of inactivated influenza virus vaccine. J Immunol. 1969 Mar;102(3):555–562. [PubMed] [Google Scholar]
  4. Waldman R. H., Mann J. J., Small P. A., Jr Immunization against influenza. Prevention of illness in man by aerosolized inactivated vaccine. JAMA. 1969 Jan 20;207(3):520–524. doi: 10.1001/jama.207.3.520. [DOI] [PubMed] [Google Scholar]

Articles from Bulletin of the World Health Organization are provided here courtesy of World Health Organization

RESOURCES