Abstract
Segregation of the haemagglutinin and neuraminidase antigens of 6 representative influenza A2 viruses and the Hong Kong virus by genetic recombination permitted a precise analysis of the antigenic constitution of each virus. Although cross-reactivity of the Hong Kong influenza virus and all 6 influenza A2 strains was demonstrated, the cross-reactivity was shown to be entirely dependent upon and mediated through the viral neuraminidase and not the haemagglutinin. The neuraminidase of the Hong Kong virus is slightly reactive with the neuraminidase of older A2 strains but is apparently identical to the enzyme of the recent (1967-68) variants.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Jahiel R. I., Kilbourne E. D. Reduction in plaque size and reduction in plaque number as differing indices of influenza virus-antibody reactions. J Bacteriol. 1966 Nov;92(5):1521–1534. doi: 10.1128/jb.92.5.1521-1534.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kilbourne E. D., Laver W. G., Schulman J. L., Webster R. G. Antiviral activity of antiserum specific for an influenza virus neuraminidase. J Virol. 1968 Apr;2(4):281–288. doi: 10.1128/jvi.2.4.281-288.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kolbourne E. D. Recombination of influenza A viruses of human and animal origin. Science. 1968 Apr 5;160(3823):74–76. doi: 10.1126/science.160.3823.74. [DOI] [PubMed] [Google Scholar]
- Laver W. G., Kilbourne E. D. Identification in a recombinant influenza virus of structural proteins derived from both parents. Virology. 1966 Nov;30(3):493–501. doi: 10.1016/0042-6822(66)90125-5. [DOI] [PubMed] [Google Scholar]
- Schulman J. L., Kilbourne E. D. Independent variation in nature of hemagglutinin and neuraminidase antigens of influenza virus: distinctiveness of hemagglutinin antigen of Hong Kong-68 virus. Proc Natl Acad Sci U S A. 1969 Jun;63(2):326–333. doi: 10.1073/pnas.63.2.326. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Webster R. G., Laver W. G., Kilbourne E. D. Reactions of antibodies with surface antigens of influenza virus. J Gen Virol. 1968 Dec;3(3):315–326. doi: 10.1099/0022-1317-3-3-315. [DOI] [PubMed] [Google Scholar]