Skip to main content
PMC home page
Bulletin of the World Health Organization logoLink to Bulletin of the World Health Organization
. 1971;45(1):85–93.

An eleven-year study of drug-resistance in Salmonella in the Netherlands*

A Manten, P A M Guinée, E H Kampelmacher, C E Voogd
PMCID: PMC2427895  PMID: 5316854

Abstract

From 1959 to 1969 a total of 123 070 strains of salmonellae, representing nearly all the strains that have been isolated from animals and man, were collected in the Netherlands and tested for antibiotic resistance.

In the course of the study, only a few strains of S. typhi and S. paratyphi B were found to be resistant to chloramphenicol, ampicillin, or tetracycline.

From 1959 to 1966 there was a sharp increase in the prevalence of tetracycline resistance in both the human and the animal strains of S. typhimurium and S. panama; subsequently, however, the prevalence declined. During 1966-70 approximately one-third of the tetracycline-resistant human and animal strains of S. typhimurium were also resistant to ampicillin. This type of multiple resistance was only occasionally encountered in the other serotypes. In contrast to resistance to tetracycline and ampicillin, the incidence of S. typhimurium resistant to chloramphenicol remained low during the whole period of observation. In all other serotypes drug resistance remained at a low level.

It is shown in this study that the greatly increased use of broad-spectrum antibiotics for medical and veterinary purposes and for animal feeding over the last decade in the Netherlands has not led to the development of serious drug resistance from the medical point of view. An important factor involved in the low incidence of resistance to chloramphenicol may be that R-factors in salmonellae usually lose this resistance determinant rapidly.

In the Netherlands the annual mortality figures for all forms of salmonellosis decreased from 0.84 (per 100 000 inhabitants) in 1961 to 0.25 in 1969.

Full text

PDF
85

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSON E. S., DATTA N. RESISTANCE TO PENICILLINS AND ITS TRANSFER IN ENTEROBACTERIACEAE. Lancet. 1965 Feb 20;1(7382):407–409. doi: 10.1016/s0140-6736(65)90004-8. [DOI] [PubMed] [Google Scholar]
  2. Aserkoff B., Bennett J. V. Effect of antibiotic therapy in acute salmonellosis on the fecal excretion of salmonellae. N Engl J Med. 1969 Sep 18;281(12):636–640. doi: 10.1056/NEJM196909182811202. [DOI] [PubMed] [Google Scholar]
  3. Bulling E., Scholz M., Malla D. S. Antibiotika-Resistenz von Enterobacterien aus Tiermaterial und Versuche zur Ubertragung der Mehrfachresistenz in vitro. Berl Munch Tierarztl Wochenschr. 1968 Apr 15;81(8):151–158. [PubMed] [Google Scholar]
  4. Lebek G. Medizinische Aspekte der infektiösen Antibiotika-Resistenz gram-negativer Darmbakterien. Pathol Microbiol (Basel) 1967;30(6):1015–1036. [PubMed] [Google Scholar]
  5. MANTEN A., KAMPELMACHER E. H., GUINEE P. A. FREQUENCY OF RESISTANCE TO TETRACYCLINE AND CHLORAMPHENICOL AMONG SALMONELLA STRAINS ISOLATED IN THE NETHERLANDS IN 1962. Antonie Van Leeuwenhoek. 1964;30:10–16. doi: 10.1007/BF02046696. [DOI] [PubMed] [Google Scholar]
  6. MANTEN A., KAMPELMACHER E. H., GUINEE P. A. Frequency of resistance to chloramphenicol and tetracyclines among 12014 Salmonella strains isolated in 1958 and 1959. Antonie Van Leeuwenhoek. 1961;27:103–109. doi: 10.1007/BF02538429. [DOI] [PubMed] [Google Scholar]
  7. MANTEN A., KAMPELMACHER E. H., GUINEE P. A. Incidence of resistance to chloramphenicol and tetracyclines among 11981 Salmonella strains isolated in 1960. Antonie Van Leeuwenhoek. 1961;27:461–464. doi: 10.1007/BF02538472. [DOI] [PubMed] [Google Scholar]
  8. MCWHORTER A. C., MURRELL M. C., EDWARDS P. R. Resistance of salmonellae isolated in 1962 to chloretetracycline. Appl Microbiol. 1963 Jul;11:368–370. doi: 10.1128/am.11.4.368-370.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. MUENNICH D., URI J., VALU G. DIE KOMBINIERTE LANGFRISTIG-HOCHDOSIERTE AMPICILLIN- AND PROBENECID-BEHANDLUNG DER TYPHUS-BAKTERIEN-DAUERAUSSCHEIDER. Chemotherapy. 1964;91:226–240. [PubMed] [Google Scholar]
  10. RAMSEY C. H., EDWARDS P. R. Resistance of Salmonellae isolated in 1959 and 1960 to tetracyclines and chloramphenicol. Appl Microbiol. 1961 Sep;9:389–391. doi: 10.1128/am.9.5.389-391.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. SLEET R. A., SANGSTER G., MURDOCH J. M. COMPARISON OF AMPICILLIN AND CHLORAMPHENICOL IN TREATMENT OF PARATYPHOID FEVER. Br Med J. 1964 Jan 18;1(5376):148–150. doi: 10.1136/bmj.1.5376.148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Schroeder S. A., Terry P. M., Bennett J. V. Antibiotic resistance and transfer factor in Salmonella, United States 1967. JAMA. 1968 Sep 23;205(13):903–906. [PubMed] [Google Scholar]
  13. Simon H. J., Miller R. C. Ampicillin in the treatment of chronic typhoid carriers. Report on fifteen treated cases and a review of the literature. N Engl J Med. 1966 Apr 14;274(15):807–815. doi: 10.1056/NEJM196604142741501. [DOI] [PubMed] [Google Scholar]
  14. Smith H. W., Halls S. Observations on infective drug resistance in Britain. Br Med J. 1966 Jan 29;1(5482):266–269. doi: 10.1136/bmj.1.5482.266. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Voogd C. E., Guinée P. A., Manten A., Kampelmacher E. H. Incidence of resistance to tetracycline, chloramphenicol and ampicillin among Salmonella species isolated in The Netherlands in 1965 and 1966. Antonie Van Leeuwenhoek. 1968;34(3):357–364. doi: 10.1007/BF02046458. [DOI] [PubMed] [Google Scholar]
  16. WATANABE T., OGATA C., SATO S. EPISOME-MEDIATED TRANSFER OF DRUG RESISTANCE IN ENTEROBACTERIACEAE. 8. SIX-DRUG-RESISTANCE R FACTOR. J Bacteriol. 1964 Oct;88:922–928. doi: 10.1128/jb.88.4.922-928.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. WHITBY J. M. AMPICILLIN IN TREATMENT OF SALMONELLA TYPHI CARRIERS. Lancet. 1964 Jul 11;2(7350):71–72. doi: 10.1016/s0140-6736(64)90071-6. [DOI] [PubMed] [Google Scholar]
  18. WOODWARD T. E., SMADEL J. E., PARKER R. T., WISSEMAN C. L., Jr Treatment of typhoid fever with antibiotics. Ann N Y Acad Sci. 1952 Dec 30;55(6):1043–1055. doi: 10.1111/j.1749-6632.1952.tb22663.x. [DOI] [PubMed] [Google Scholar]
  19. Walton J. R. Infectious drug resistance in Escherichia coli isolated from healthy farm animals. Lancet. 1966 Dec 10;2(7476):1300–1302. doi: 10.1016/s0140-6736(66)91705-3. [DOI] [PubMed] [Google Scholar]
  20. YURACK J. A. RESISTANCE OF SALMONELLAE ISOLATED IN 1962 TO TETRACYCLINE, CHLORAMPHENICOL, AND AMPICILLIN. Can J Microbiol. 1964 Aug;10:521–526. doi: 10.1139/m64-065. [DOI] [PubMed] [Google Scholar]

Articles from Bulletin of the World Health Organization are provided here courtesy of World Health Organization

RESOURCES