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. 1971;45(2):157–167.

Chloroquine resistance of Plasmodium falciparum in Brazil detected by a simple in vitro method*

Karl H Rieckmann, Francisco J López Antuñano
PMCID: PMC2427915  PMID: 4945631

Abstract

The sensitivity of Plasmodium falciparum to antimalarial drugs is primarily determined by observing changes in the level of parasitaemia after administration of drugs to man. Performance of such a study and interpretation of its results may present certain difficulties, especially when conducted among persons living in malarious areas. The present study was conducted to evaluate the usefulness of a simple in vitro method for detecting chloroquine-resistant strains among infected residents of Mato Grosso, Brazil. The findings indicated the participants were infected with chloroquine-resistant P. falciparum. Subsequent administration of a standard regimen of chloroquine (25 mg/kg) to these subjects confirmed the findings observed in vitro by failing to cure 28 out of 30 infections. This in vitro technique seems to provide a useful method of determining the presence or prevalence of chloroquine-resistant strains in a given area.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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