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Bulletin of the World Health Organization logoLink to Bulletin of the World Health Organization
. 1971;45(3):291–293.

Meningococcal infections*

5. Duration of polysaccharide-vaccine-induced antibody

Malcolm S Artenstein
PMCID: PMC2427925  PMID: 4947213

Abstract

Serum antibodies induced in 12 volunteer subjects by injection of group A and group C meningococcal polysaccharide vaccines were found to persist for periods exceeding 14 months. Antibody response was measured by indirect haemagglutination and fluorescent antibody assays. Peak titres were reached in 2-8 weeks.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Artenstein M. S., Gold R., Zimmerly J. G., Wyle F. A., Branche W. C., Jr, Harkins C. Cutaneous reactions and antibody response to meningococcal group C polysaccharide vaccines in man. J Infect Dis. 1970 Apr;121(4):372–377. doi: 10.1093/infdis/121.4.372. [DOI] [PubMed] [Google Scholar]
  2. Goldschneider I., Gotschlich E. C., Artenstein M. S. Human immunity to the meningococcus. I. The role of humoral antibodies. J Exp Med. 1969 Jun 1;129(6):1307–1326. doi: 10.1084/jem.129.6.1307. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Goldschneider I., Gotschlich E. C., Artenstein M. S. Human immunity to the meningococcus. II. Development of natural immunity. J Exp Med. 1969 Jun 1;129(6):1327–1348. doi: 10.1084/jem.129.6.1327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gotschlich E. C., Goldschneider I., Artenstein M. S. Human immunity to the meningococcus. IV. Immunogenicity of group A and group C meningococcal polysaccharides in human volunteers. J Exp Med. 1969 Jun 1;129(6):1367–1384. doi: 10.1084/jem.129.6.1367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gotschlich E. C., Liu T. Y., Artenstein M. S. Human immunity to the meningococcus. 3. Preparation and immunochemical properties of the group A, group B, and group C meningococcal polysaccharides. J Exp Med. 1969 Jun 1;129(6):1349–1365. doi: 10.1084/jem.129.6.1349. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Heidelberger M., Macleod C. M., Kaiser S. J., Robinson B. ANTIBODY FORMATION IN VOLUNTEERS FOLLOWING INJECTION OF PNEUMOCOCCI OR THEIR TYPE-SPECIFIC POLYSACCHARIDES. J Exp Med. 1946 Mar 31;83(4):303–320. [PMC free article] [PubMed] [Google Scholar]
  7. Roberts R. B. The relationship between group A and group C meningococcal polysaccharides and serum opsonins in man. J Exp Med. 1970 Mar 1;131(3):499–513. doi: 10.1084/jem.131.3.499. [DOI] [PMC free article] [PubMed] [Google Scholar]

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