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. 1971;44(1-2-3):193–202.

Resistance in insects: the role of metabolism and the possible use of synergists

F J Oppenoorth
PMCID: PMC2428052  PMID: 5315343

Abstract

The use of synergists to prevent detoxification raises two principal problems: (1) the importance of detoxification as a resistance mechanism and the extent to which synergists could contribute to a solution of the resistance problem, and (2) the role of detoxification as a cause of selectivity, and whether the loss in selectivity that might result from the use of synergists would be a disadvantage. If insecticides could be combined with detoxification-blocking synergists, a much wider range of insecticides might become available for use.

This paper also discusses the relative importance of different routes of detoxification, whether to use a constant synergist—insecticide ratio, and some recent work carried out in the author's laboratory on microsomal oxidation of paraoxon and on the synergistic action of P=S compounds.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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