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. 1987 Apr;63(738):241–244. doi: 10.1136/pgmj.63.738.241

Growth hormone responses to hp GRF 1-44 amide, bromocriptine and stress in acromegaly are correlated.

P E Belchetz 1
PMCID: PMC2428167  PMID: 3120167

Abstract

The results of testing growth hormone (GH) reserve using human pancreatic growth hormone-releasing factor 1-44 amide (hp GRF 1-44 amide) have been compared with the GH responses in a variety of other dynamic tests in seven acromegalic patients. The GH release following hp GRF 1-44 amide correlated with the GH suppression following bromocriptine, but showed an inverse correlation with the GH release following stress tests (insulin-induced hypoglycaemia/glucagon). There was no correlation between the GH responses in these three tests and any of the other tests: TRH, GnRH and glucose. A hypothesis is proposed to explain these findings on the basis of varying degrees of GH secretion from adenomatous and normal pituitary somatotrophs in acromegaly.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Belchetz P. E., Weldon S. F., Davis J. C., Diver M. J., Smith C. S., Harris F. Potential uses of human pancreatic growth hormone-releasing factor 1-44 amide. Clin Endocrinol (Oxf) 1984 Aug;21(2):201–208. doi: 10.1111/j.1365-2265.1984.tb03460.x. [DOI] [PubMed] [Google Scholar]
  2. Böhlen P., Brazeau P., Bloch B., Ling N., Gaillard R., Guillemin R. Human hypothalamic growth hormone releasing factor (GRF): evidence for two forms identical to tumor derived GRF-44-NH2 and GRF-40. Biochem Biophys Res Commun. 1983 Aug 12;114(3):930–936. doi: 10.1016/0006-291x(83)90649-6. [DOI] [PubMed] [Google Scholar]
  3. Chiodini P. G., Liuzzi A., Dallabonzana D., Oppizzi G., Verde G. G. Changes in growth hormone (GH) secretion induced by human pancreatic GH releasing hormone-44 in acromegaly: a comparison with thyrotropin-releasing hormone and bromocriptine. J Clin Endocrinol Metab. 1985 Jan;60(1):48–52. doi: 10.1210/jcem-60-1-48. [DOI] [PubMed] [Google Scholar]
  4. Gelato M. C., Merriam G. R., Vance M. L., Goldman J. A., Webb C., Evans W. S., Rock J., Oldfield E. H., Molitch M. E., Rivier J. Effects of growth hormone-releasing factor on growth hormone secretion in acromegaly. J Clin Endocrinol Metab. 1985 Feb;60(2):251–257. doi: 10.1210/jcem-60-2-251. [DOI] [PubMed] [Google Scholar]
  5. Guillemin R., Brazeau P., Böhlen P., Esch F., Ling N., Wehrenberg W. B. Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. Science. 1982 Nov 5;218(4572):585–587. doi: 10.1126/science.6812220. [DOI] [PubMed] [Google Scholar]
  6. Liuzzi A., Chiodini P. G., Botalla L., Silvestrini F., Müller E. E. Growth hormone (GH)-releasing activity of TRH and GH-lowering effect of dopaminergic drugs in acromegaly: homogeneity in the two responses. J Clin Endocrinol Metab. 1974 Nov;39(5):871–876. doi: 10.1210/jcem-39-5-871. [DOI] [PubMed] [Google Scholar]
  7. Penny E. S., Penman E., Price J., Rees L. H., Sopwith A. M., Wass J. A., Lytras N., Besser G. M. Circulating growth hormone releasing factor concentrations in normal subjects and patients with acromegaly. Br Med J (Clin Res Ed) 1984 Aug 25;289(6443):453–455. doi: 10.1136/bmj.289.6443.453. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Pieters G. F., Smals A. E., Hermus A. R., Smals A. G., Benraad T. J., Kloppenborg P. W. Growth hormone responsiveness to human pancreatic growth hormone releasing factor in acromegaly: modulatory effects of basal hormone levels and of concomitant somatostatin administration. Clin Endocrinol (Oxf) 1984 Dec;21(6):701–707. doi: 10.1111/j.1365-2265.1984.tb01412.x. [DOI] [PubMed] [Google Scholar]
  9. Rivier J., Spiess J., Thorner M., Vale W. Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour. Nature. 1982 Nov 18;300(5889):276–278. doi: 10.1038/300276a0. [DOI] [PubMed] [Google Scholar]
  10. Shibasaki T., Shizume K., Masuda A., Nakahara M., Hizuka N., Miyakawa M., Takano K., Demura H., Wakabayashi I., Ling N. Plasma growth hormone response to growth hormone-releasing factor in acromegalic patients. J Clin Endocrinol Metab. 1984 Jan;58(1):215–217. doi: 10.1210/jcem-58-1-215. [DOI] [PubMed] [Google Scholar]
  11. Wood S. M., Ch'ng J. L., Adams E. F., Webster J. D., Joplin G. F., Mashiter K., Bloom S. R. Abnormalities of growth hormone release in response to human pancreatic growth hormone releasing factor (GRF (1-44) ) in acromegaly and hypopituitarism. Br Med J (Clin Res Ed) 1983 May 28;286(6379):1687–1691. doi: 10.1136/bmj.286.6379.1687. [DOI] [PMC free article] [PubMed] [Google Scholar]

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