Skip to main content
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1987 Mar;63(737):205–207. doi: 10.1136/pgmj.63.737.205

Macrocytic anaemia due to copper deficiency in a patient with late onset hypogammaglobulinaemia.

S M Oppenheimer 1, B I Hoffbrand 1, T L Dormandy 1, N Parker 1, D G Wickens 1
PMCID: PMC2428298  PMID: 3671260

Abstract

Very few cases of acquired severe copper deficiency have been described. The principal effects are haematological, but the precise abnormalities are uncertain due to the possible association of other deficiencies. A case of isolated severe copper deficiency associated with late onset hypogammaglobulinaemia is reported in which the chief findings were macrocytic anaemia, neutropenia and a decrease in mean platelet volume. All these abnormalities resolved when copper therapy was instituted and recurred when the medication was stopped.

Full text

PDF
205

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ashkenazi A., Levin S., Djaldetti M., Fishel E., Benvenisti D. The syndrome of neonatal copper deficiency. Pediatrics. 1973 Oct;52(4):525–533. [PubMed] [Google Scholar]
  2. CORDANO A., BAERTL J. M., GRAHAM G. G. COPPER DEFICIENCY IN INFANCY. Pediatrics. 1964 Sep;34:324–336. [PubMed] [Google Scholar]
  3. Cordano A., Grahma G. G. Copper deficiency complicating severe chronic intestinal malabsorption. Pediatrics. 1966 Oct;38(4):596–604. [PubMed] [Google Scholar]
  4. Cordano A., Placko R. P., Graham G. G. Hypocupremia and neutropenia in copper deficiency. Blood. 1966 Aug;28(2):280–283. [PubMed] [Google Scholar]
  5. Dunlap W. M., James G. W., 3rd, Hume D. M. Anemia and neutropenia caused by copper deficiency. Ann Intern Med. 1974 Apr;80(4):470–476. doi: 10.7326/0003-4819-80-4-470. [DOI] [PubMed] [Google Scholar]
  6. Graham G. G., Cordano A. Copper depletion and deficiency in the malnourished infant. Johns Hopkins Med J. 1969 Mar;124(3):139–150. [PubMed] [Google Scholar]
  7. Gutteridge J. M., Stocks J. Caeruloplasmin: physiological and pathological perspectives. Crit Rev Clin Lab Sci. 1981;14(4):257–329. doi: 10.3109/10408368109105866. [DOI] [PubMed] [Google Scholar]
  8. Karpel J. T., Peden V. H. Copper deficiency in long-term parenteral nutrition. J Pediatr. 1972 Jan;80(1):32–36. doi: 10.1016/s0022-3476(72)80449-9. [DOI] [PubMed] [Google Scholar]
  9. LAHEY M. E., GUBLER C. J., CHASE M. S., CARTWRIGHT G. E., WINTROBE M. M. Studies on copper metabolism. II. Hematologic manifestations of copper deficiency in swine. Blood. 1952 Nov;7(11):1053–1074. [PubMed] [Google Scholar]
  10. Lee G. R., Nacht S., Lukens J. N., Cartwright G. E. Iron metabolism in copper-deficient swine. J Clin Invest. 1968 Sep;47(9):2058–2069. doi: 10.1172/JCI105891. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Levy Y., Zeharia A., Grunebaum M., Nitzan M., Steinherz R. Copper deficiency in infants fed cow milk. J Pediatr. 1985 May;106(5):786–788. doi: 10.1016/s0022-3476(85)80356-5. [DOI] [PubMed] [Google Scholar]
  12. Patterson W. P., Winkelmann M., Perry M. C. Zinc-induced copper deficiency: megamineral sideroblastic anemia. Ann Intern Med. 1985 Sep;103(3):385–386. doi: 10.7326/0003-4819-103-3-385. [DOI] [PubMed] [Google Scholar]
  13. Prohaska J. R., Lukasewycz O. A. Copper deficiency suppresses the immune response of mice. Science. 1981 Jul 31;213(4507):559–561. doi: 10.1126/science.7244654. [DOI] [PubMed] [Google Scholar]
  14. Vilter R. W., Bozian R. C., Hess E. V., Zellner D. C., Petering H. G. Manifestations of copper deficiency in a patient with systemic sclerosis on intravenous hyperalimentation. N Engl J Med. 1974 Jul 25;291(4):188–191. doi: 10.1056/NEJM197407252910407. [DOI] [PubMed] [Google Scholar]
  15. Williams D. M. Copper deficiency in humans. Semin Hematol. 1983 Apr;20(2):118–128. [PubMed] [Google Scholar]
  16. Zidar B. L., Shadduck R. K., Zeigler Z., Winkelstein A. Observations on the anemia and neutropenia of human copper deficiency. Am J Hematol. 1977;3:177–185. doi: 10.1002/ajh.2830030209. [DOI] [PubMed] [Google Scholar]
  17. al-Rashid R. A., Spangler J. Neonatal copper deficiency. N Engl J Med. 1971 Oct 7;285(15):841–843. doi: 10.1056/NEJM197110072851506. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES