Abstract
Hypothyroid myopathy has so far been reported in long standing cases of hypothyroidism. We describe two adult patients with myopathy associated with acute transient hypothyroidism. Both presented with severe muscle aches and cramps, stiffness and spasms. Muscle enzymes were markedly elevated and electromyography in one patient showed myopathic features. Histological changes were absent in muscle biopsy, probably because of the short duration of metabolic disturbance. The myopathy subsided promptly when the hypothyroid state was reversed.
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Selected References
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- ASTROM K. E., KUGELBERG E., MULLER R. Hypothyroid myopathy. Arch Neurol. 1961 Nov;5:472–482. doi: 10.1001/archneur.1961.00450170010002. [DOI] [PubMed] [Google Scholar]
- COLLINS J. A., Jr, ZIMMER F. E., JOHNSON W. J., KOUGH R. H. THE MANY FACES OF HYPOTHYROIDISM. Postgrad Med. 1964 Oct;36:371–384. doi: 10.1080/00325481.1964.11695294. [DOI] [PubMed] [Google Scholar]
- Griffiths P. D. Serum enzymes in diseases of the thyroid gland. J Clin Pathol. 1965 Sep;18(5):660–663. doi: 10.1136/jcp.18.5.660. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Khaleeli A. A., Gohil K., McPhail G., Round J. M., Edwards R. H. Muscle morphology and metabolism in hypothyroid myopathy: effects of treatment. J Clin Pathol. 1983 May;36(5):519–526. doi: 10.1136/jcp.36.5.519. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McKeran R. O., Slavin G., Andrews T. M., Ward P., Mair W. G. Muscle fibre type changes in hypothyroid myopathy. J Clin Pathol. 1975 Aug;28(8):659–663. doi: 10.1136/jcp.28.8.659. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McKeran R. O., Ward P., Slavin G., Paul E. A. Central nuclear counts in muscle fibres before and during treatment in hypothyroid myopathy. J Clin Pathol. 1979 Mar;32(3):229–233. doi: 10.1136/jcp.32.3.229. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NAJJAR S. S., NACHMAN H. S. THE KOCHER-DEBR'E-S'EM'ELAIGNE SYNDROME; HYPOTHYROIDISM WITH MUSCULAR "HYPERTROPHY". J Pediatr. 1965 May;66:901–908. doi: 10.1016/s0022-3476(65)80066-x. [DOI] [PubMed] [Google Scholar]
- Norris F. H., Jr, Panner B. J. Hypothyroid myopathy. Clinical, electromyographical, and ultrastructural observations. Arch Neurol. 1966 Jun;14(6):574–589. doi: 10.1001/archneur.1966.00470120006002. [DOI] [PubMed] [Google Scholar]
- PERUGINI S., PRATI P. L. Su due casi familiari di mixedema acquisito decorrenti con distrofia muscolare (miopatia ipotiroidea). Minerva Med. 1957 Dec 1;48(96):4060–4067. [PubMed] [Google Scholar]
- WILSON J., WALTON J. N. Some muscular manifestations of hypothyroidism. J Neurol Neurosurg Psychiatry. 1959 Nov;22:320–324. doi: 10.1136/jnnp.22.4.320. [DOI] [PMC free article] [PubMed] [Google Scholar]