Abstract
A 65 year old man developed atrial arrhythmias secondary to a congestive cardiomyopathy which were resistant to quinidine and disopyramide. Amiodarone controlled the paroxysmal atrial tachycardia but 4 months after starting the drug he developed increasing dyspnoea and radiological changes highly suggestive of metastatic lung disease. Lung biopsy showed change of drug-induced pneumonitis and 4 months after stopping amiodarone his symptoms resolved and the chest X-ray had cleared. Amiodarone may cause pulmonary toxicity mimicking metastatic lung disease.
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- Darmanata J. I., van Zandwijk N., Düren D. R., van Royen E. A., Mooi W. J., Plomp T. A., Jansen H. M., Durrer D. Amiodarone pneumonitis: three further cases with a review of published reports. Thorax. 1984 Jan;39(1):57–64. doi: 10.1136/thx.39.1.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Marchlinski F. E., Gansler T. S., Waxman H. L., Josephson M. E. Amiodarone pulmonary toxicity. Ann Intern Med. 1982 Dec;97(6):839–845. doi: 10.7326/0003-4819-97-6-839. [DOI] [PubMed] [Google Scholar]
- McGovern B., Garan H., Kelly E., Ruskin J. N. Adverse reactions during treatment with amiodarone hydrochloride. Br Med J (Clin Res Ed) 1983 Jul 16;287(6386):175–180. doi: 10.1136/bmj.287.6386.175. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rakita L., Sobol S. M., Mostow N., Vrobel T. Amiodarone pulmonary toxicity. Am Heart J. 1983 Oct;106(4 Pt 2):906–916. doi: 10.1016/0002-8703(83)90015-7. [DOI] [PubMed] [Google Scholar]
- Rotmensch H. H., Liron M., Tupilski M., Laniado S. Possible association of pneumonitis with amiodarone therapy. Am Heart J. 1980 Sep;100(3):412–413. doi: 10.1016/0002-8703(80)90165-9. [DOI] [PubMed] [Google Scholar]
- Suárez L. D., Poderoso J. J., Elsner B., Bunster A. M., Esteva H., Bellotti M. Subacute pneumopathy during amiodarone therapy. Chest. 1983 Mar;83(3):566–568. doi: 10.1378/chest.83.3.566. [DOI] [PubMed] [Google Scholar]
- Zaher C., Hamer A., Peter T., Mandel W. Low-dose steroid therapy for prophylaxis of amiodarone-induced pulmonary infiltrates. N Engl J Med. 1983 Mar 31;308(13):779–779. doi: 10.1056/NEJM198303313081317. [DOI] [PubMed] [Google Scholar]


