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. 1988 Apr;64(750):264–266. doi: 10.1136/pgmj.64.750.264

The low plasma testosterone levels of young Indian infarct survivors are not due to a primary testicular defect.

M Sewdarsen 1, I Jialal 1, R K Naidu 1
PMCID: PMC2428505  PMID: 3186567

Abstract

A case control study was performed to determine whether the hypotestosteronaemia described in men with coronary artery disease could be the result of primary testicular dysfunction. Testicular function was assessed by comparing the response of 10 young Indian men with myocardial infarction to human chorionic gonadotrophin (HCG) injection to that of 10 healthy age and weight matched controls. The basal testosterone levels in the patients were significantly lower (12.71 +/- 1.36 nmol/l vs 16.51 +/- 0.79 nmol/l; P = 0.01) and the basal oestradiol levels significantly higher than the controls (120.67 +/- 8.81 pmol/l vs 94.05 +/- 8.23 pmol/l; P = 0.02). There was no difference in the sex hormone binding globulin concentrations. However, following HCG stimulation the patients demonstrated a normal response with a 2-fold increase in testosterone. There was no difference in the testosterone and oestradiol levels of the patients and controls following HCG stimulation. This normal response in our patients demonstrates that the hypotestosteronaemia in Indian men with myocardial infarction is not due to a primary testicular dysfunction but probably is a result of increased aromatization of testosterone to oestradiol.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Breier C., Mühlberger V., Drexel H., Herold M., Lisch H. J., Knapp E., Braunsteiner H. Essential role of post-heparin lipoprotein lipase activity and of plasma testosterone in coronary artery disease. Lancet. 1985 Jun 1;1(8440):1242–1244. doi: 10.1016/s0140-6736(85)92313-x. [DOI] [PubMed] [Google Scholar]
  2. Entrican J. H., Beach C., Carroll D., Klopper A., Mackie M., Douglas A. S. Raised plasma oestradiol and oestrone levels in young survivors of myocardial infarction. Lancet. 1978 Sep 2;2(8088):487–490. doi: 10.1016/s0140-6736(78)92215-8. [DOI] [PubMed] [Google Scholar]
  3. Klaiber E. L., Broverman D. M., Haffajee C. I., Hochman J. S., Sacks G. M., Dalen J. E. Serum estrogen levels in men with acute myocardial infarction. Am J Med. 1982 Dec;73(6):872–881. doi: 10.1016/0002-9343(82)90779-3. [DOI] [PubMed] [Google Scholar]
  4. Lindholm J., Winkel P., Brodthagen U., Gyntelberg F. Coronary risk factors and plasma sex hormones. Am J Med. 1982 Nov;73(5):648–651. doi: 10.1016/0002-9343(82)90405-3. [DOI] [PubMed] [Google Scholar]
  5. Longcope C., Pratt J. H., Schneider S. H., Fineberg S. E. Aromatization of androgens by muscle and adipose tissue in vivo. J Clin Endocrinol Metab. 1978 Jan;46(1):146–152. doi: 10.1210/jcem-46-1-146. [DOI] [PubMed] [Google Scholar]
  6. McDonald L., Baker C., Bray C., McDonald A., Restieaux N. Plasma-catecholamines after cardiac infarction. Lancet. 1969 Nov 15;2(7629):1021–1023. doi: 10.1016/s0140-6736(69)90637-0. [DOI] [PubMed] [Google Scholar]
  7. Nirmul D., Pegoraro R. J., Jialal I., Naidoo C., Joubert S. M. The sex hormone profile of male patients with breast cancer. Br J Cancer. 1983 Sep;48(3):423–427. doi: 10.1038/bjc.1983.208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Phillips G. B. Evidence for hyperoestrogenaemia as a risk factor for myocardial infarction in men. Lancet. 1976 Jul 3;2(7975):14–18. doi: 10.1016/s0140-6736(76)92968-8. [DOI] [PubMed] [Google Scholar]
  9. Poggi U. L., Argüelles A. E., Rosner J., de Laborde N. P., Cassini J. H., Volmer M. C. Plasma testosterone and serum lipids in male survivors of myocardial infarction. J Steroid Biochem. 1976 Mar;7(3):229–231. doi: 10.1016/0022-4731(76)90206-5. [DOI] [PubMed] [Google Scholar]
  10. Schneider G., Kirschner M. A., Berkowitz R., Ertel N. H. Increased estrogen production in obese men. J Clin Endocrinol Metab. 1979 Apr;48(4):633–638. doi: 10.1210/jcem-48-4-633. [DOI] [PubMed] [Google Scholar]
  11. Sewdarsen M., Jialal I., Vythilingum S., Desai R. Sex hormone levels in young Indian patients with myocardial infarction. Arteriosclerosis. 1986 Jul-Aug;6(4):418–421. doi: 10.1161/01.atv.6.4.418. [DOI] [PubMed] [Google Scholar]
  12. Verhoeven G., Dierickx P., de Moor P. Stimulation effect of neurotransmitters on the aromatization of testosterone by Sertoli cell-enriched cultures. Mol Cell Endocrinol. 1979 Mar;13(3):241–253. doi: 10.1016/0303-7207(79)90084-4. [DOI] [PubMed] [Google Scholar]

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