Skip to main content
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1987 Sep;63(743):777–779. doi: 10.1136/pgmj.63.743.777

Combined irradiation and low-dose cyclophosphamide in the treatment of Graves' ophthalmopathy.

R Teoh 1, J Woo 1
PMCID: PMC2428524  PMID: 3444803

Abstract

The treatment of a patient with euthyroid Graves' ophthalmopathy is described. A poor response was obtained from large doses of prednisone whereas a combination of orbital irradiation and low dose cyclophosphamide induced a dramatic resolution. As there is no fully satisfactory treatment for this condition, this combined therapy deserves further investigation.

Full text

PDF
777

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bartalena L., Marcocci C., Chiovato L., Laddaga M., Lepri G., Andreani D., Cavallacci G., Baschieri L., Pinchera A. Orbital cobalt irradiation combined with systemic corticosteroids for Graves' ophthalmopathy: comparison with systemic corticosteroids alone. J Clin Endocrinol Metab. 1983 Jun;56(6):1139–1144. doi: 10.1210/jcem-56-6-1139. [DOI] [PubMed] [Google Scholar]
  2. Faryna M., Nauman J., Gardas A. Measurement of autoantibodies against human eye muscle plasma membranes in Graves' ophthalmopathy. Br Med J (Clin Res Ed) 1985 Jan 19;290(6463):191–192. doi: 10.1136/bmj.290.6463.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Howlett T. A., Lawton N. F., Fells P., Besser G. M. Deterioration of severe Graves' ophthalmopathy during cyclosporin treatment. Lancet. 1984 Nov 10;2(8411):1101–1101. doi: 10.1016/s0140-6736(84)91541-1. [DOI] [PubMed] [Google Scholar]
  4. Kodama K., Sikorska H., Bandy-Dafoe P., Bayly R., Wall J. R. Demonstration of a circulating autoantibody against a soluble eye-muscle antigen in Graves' ophthalmopathy. Lancet. 1982 Dec 18;2(8312):1353–1356. doi: 10.1016/s0140-6736(82)91267-3. [DOI] [PubMed] [Google Scholar]
  5. Pestronk A., Drachman D. B., Teoh R., Adams R. N. Combined short-term immunotherapy for experimental autoimmune myasthenia gravis. Ann Neurol. 1983 Aug;14(2):235–241. doi: 10.1002/ana.410140210. [DOI] [PubMed] [Google Scholar]
  6. Weetman A. P., McGregor A. M., Hall R. Ocular manifestations of Graves' disease: a review. J R Soc Med. 1984 Nov;77(11):936–942. doi: 10.1177/014107688407701109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Weetman A. P., McGregor A. M., Ludgate M., Beck L., Mills P. V., Lazarus J. H., Hall R. Cyclosporin improves Graves' ophthalmopathy. Lancet. 1983 Aug 27;2(8348):486–489. doi: 10.1016/s0140-6736(83)90514-7. [DOI] [PubMed] [Google Scholar]
  8. Werner S. C., Coleman D. J., Franzen L. A. Ultrasonographic evidence of a consistent orbital involvement in Graves's disease. N Engl J Med. 1974 Jun 27;290(26):1447–1450. doi: 10.1056/NEJM197406272902602. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES