Skip to main content
NCBI home page
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1987 Sep;63(743):745–750. doi: 10.1136/pgmj.63.743.745

The incidence and causes of hypercalcaemia.

D M Dent 1, J L Miller 1, L Klaff 1, J Barron 1
PMCID: PMC2428526  PMID: 3444797

Abstract

A prospective screen for hypercalcaemia in 58,053 hospital in-patients was conducted over 12 months. The incidence of hypercalcaemia was 0.6%, being transient in 19.2% of patients and sustained in the remainder. The most common causes in the sustained group were malignancy (45%) and primary hyperparathyroidism (16.5%). The incidence of primary hyperparathyroidism was 78/100,000 hospital in-patients, and its discovery was directly attributable to the survey in over half the cases.

Full text

PDF
745

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOONSTRA C. E., JACKSON C. E. HYPERPARATHYROIDISM DETECTED BY ROUTINE SERUM CALCIUM ANALYSIS. PREVALENCE IN A CLINIC POPULATION. Ann Intern Med. 1965 Sep;63:468–474. doi: 10.7326/0003-4819-63-3-468. [DOI] [PubMed] [Google Scholar]
  2. BOONSTRA C. E., JACKSON C. E. The clinical value of routine serum calcium analysis. Ann Intern Med. 1962 Dec;57:963–969. doi: 10.7326/0003-4819-57-6-963. [DOI] [PubMed] [Google Scholar]
  3. Boonstra C. E., Jackson C. E. Serum calcium survey for hyperparathyroidism: results in 50,000 clinic patients. Am J Clin Pathol. 1971 May;55(5):523–526. doi: 10.1093/ajcp/55.5.523. [DOI] [PubMed] [Google Scholar]
  4. Burkhardt E., Kistler H. J. Hypercalciämie bei hospitalisierten Patienten. Diagnostische und prognostische Aspekte. Schweiz Med Wochenschr. 1981 Dec 19;111(51):2017–2023. [PubMed] [Google Scholar]
  5. Burt M. E., Brennan M. F. Incidence of hypercalcemia and malignant neoplasm. Arch Surg. 1980 Jun;115(6):704–707. doi: 10.1001/archsurg.1980.01380060012004. [DOI] [PubMed] [Google Scholar]
  6. Christensson T. Familial hyperparathyroidism. Ann Intern Med. 1976 Nov;85(5):614–615. doi: 10.7326/0003-4819-85-5-614. [DOI] [PubMed] [Google Scholar]
  7. Christensson T., Hellström K., Wengle B., Alveryd A., Wikland B. Prevalence of hypercalcaemia in a health screening in Stockholm. Acta Med Scand. 1976;200(1-2):131–137. doi: 10.1111/j.0954-6820.1976.tb08208.x. [DOI] [PubMed] [Google Scholar]
  8. Christensson T., Hellström K., Wengle B. Clinical and laboratory findings in subjects with hypercalcaemia. A study including cases with primary hyperparathyroidism detected in a health screening. Acta Med Scand. 1976;200(5):355–360. [PubMed] [Google Scholar]
  9. Fisken R. A., Heath D. A., Bold A. M. Hypercalcaemia--a hospital survey. Q J Med. 1980 Autumn;49(196):405–418. [PubMed] [Google Scholar]
  10. Fisken R. A., Heath D. A., Somers S., Bold A. M. Hypercalcaemia in hospital patients. Clinical and diagnostic aspects. Lancet. 1981 Jan 24;1(8213):202–207. doi: 10.1016/s0140-6736(81)90071-4. [DOI] [PubMed] [Google Scholar]
  11. Haff R. C., Black W. C., Ballinger W. F. Primary hyperparathyroidism: changing clinical, surgical and pathologic aspects. Ann Surg. 1970 Jan;171(1):85–92. doi: 10.1097/00000658-197001000-00013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Harrop J. S., Bailey J. E., Woodhead J. S. Incidence of hypercalcaemia and primary hyperparathyroidism in relation to the biochemical profile. J Clin Pathol. 1982 Apr;35(4):395–400. doi: 10.1136/jcp.35.4.395. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Heath H., 3rd, Hodgson S. F., Kennedy M. A. Primary hyperparathyroidism. Incidence, morbidity, and potential economic impact in a community. N Engl J Med. 1980 Jan 24;302(4):189–193. doi: 10.1056/NEJM198001243020402. [DOI] [PubMed] [Google Scholar]
  14. Heedman P. A., Stenström G. Clinical findings in patients with hypercalcaemia. A preliminary investigation based on biochemical screening. Acta Med Scand. 1973 Mar;193(3):167–173. [PubMed] [Google Scholar]
  15. KEATING F. R., Jr Diagnosis of primary hyperparathyroidism. Clinical and laboratory aspects. JAMA. 1961 Nov 11;178:547–555. doi: 10.1001/jama.1961.03040450011003. [DOI] [PubMed] [Google Scholar]
  16. Keating F. R., Jr, Jones J. D., Elveback L. R. Distribution of serum calcium and phosphorus values in unselected ambulatory patients. J Lab Clin Med. 1969 Sep;74(3):507–514. [PubMed] [Google Scholar]
  17. Lo Cascio V., Vallaperta P., Adami S., Cominacini L., Galvanini G., Bianchi I., Ferrari M., Scuro L. A. Discriminant analysis in the differential diagnosis of hypercalcaemia. Clin Endocrinol (Oxf) 1978 Apr;8(4):349–356. doi: 10.1111/j.1365-2265.1978.tb02777.x. [DOI] [PubMed] [Google Scholar]
  18. Parfitt A. M. Chlorothiazide-induced hypercalcemia in juvenile osteoporosis and hyperparathyroidism. N Engl J Med. 1969 Jul 10;281(2):55–59. doi: 10.1056/NEJM196907102810201. [DOI] [PubMed] [Google Scholar]
  19. Rajathurai A., Cove-Smith R. Hypercalcaemia in Cleveland: a hospital-based survey. J R Soc Med. 1984 Sep;77(9):742–746. doi: 10.1177/014107688407700906. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Stenström G., Heedman P. A. Clinical findings in patients with hypercalcaemia. A final investigation based on biochemical screening. Acta Med Scand. 1974 Jun;195(6):473–477. doi: 10.1111/j.0954-6820.1974.tb08174.x. [DOI] [PubMed] [Google Scholar]
  21. Zawada E. T., Jr, Lee D. B., Kleeman C. R. Causes of hypercalcemia. Postgrad Med. 1979 Oct;66(4):91-7, 99-100. doi: 10.1080/00325481.1979.11715273. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES