Abstract
Eight patients with steroid-sensitive nephrotic syndrome which frequently relapsed despite cyclophosphamide treatment were given cyclosporin A (7.5 mg/kg/day to 10 mg/kg/day) for 8 to 12 weeks. Six had minimal change glomerulonephritis and two had focal segmental glomerulonephritis. Cyclosporin A was given to 5 patients when their nephrotic syndrome was in relapse and to 3 patients when the nephrotic syndrome was in remission. Cyclosporin A induced a transient remission in only one patient.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Capodicasa G., De Santo N. G., Nuzzi F., Giordano C. Cyclosporin A in nephrotic syndrome of childhood--a 14 month experience. Int J Pediatr Nephrol. 1986 Apr-Jun;7(2):69–72. [PubMed] [Google Scholar]
- Hoyer P. F., Krull F., Brodehl J. Cyclosporin in frequently relapsing minimal change nephrotic syndrome. Lancet. 1986 Aug 9;2(8502):335–335. doi: 10.1016/s0140-6736(86)90017-6. [DOI] [PubMed] [Google Scholar]
- Lagrue C., Laurent J., Belghiti D., Robeva R. Cyclosporin and idiopathic nephrotic syndrome. Lancet. 1986 Sep 20;2(8508):692–693. doi: 10.1016/s0140-6736(86)90205-9. [DOI] [PubMed] [Google Scholar]
- Matsumoto K., Osakabe K., Harada M., Hatano M. Impaired cell-mediated immunity in lipoid nephrosis. Nephron. 1981;29(3-4):190–194. doi: 10.1159/000182357. [DOI] [PubMed] [Google Scholar]
- Meadow S. R., Sarsfield J. K. Steroid-responsive and nephrotic syndrome and allergy: clinical studies. Arch Dis Child. 1981 Jul;56(7):509–516. doi: 10.1136/adc.56.7.509. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Meyrier A., Simon P., Perret G., Condamin-Meyrier M. C. Remission of idiopathic nephrotic syndrome after treatment with cyclosporin A. Br Med J (Clin Res Ed) 1986 Mar 22;292(6523):789–792. doi: 10.1136/bmj.292.6523.789. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Okudaira H., Sakurai Y., Terada K., Terada E., Ogita T., Miyamoto T. Cyclosporin A-induced suppression of ongoing IgE antibody formation in the mouse. Int Arch Allergy Appl Immunol. 1986;79(2):164–168. doi: 10.1159/000233965. [DOI] [PubMed] [Google Scholar]
- Shalhoub R. J. Pathogenesis of lipoid nephrosis: a disorder of T-cell function. Lancet. 1974 Sep 7;2(7880):556–560. doi: 10.1016/s0140-6736(74)91880-7. [DOI] [PubMed] [Google Scholar]
- Tipping P. G., Holdsworth S. R. Effect of cyclosporin A on antibody-induced experimental glomerulonephritis. Nephron. 1985;40(2):201–205. doi: 10.1159/000190341. [DOI] [PubMed] [Google Scholar]
- Voets A. J., Hoitsma A. J., Koene R. A. Recurrence of nephrotic syndrome during cyclosporin treatment after renal transplantation. Lancet. 1986 Feb 1;1(8475):266–267. doi: 10.1016/s0140-6736(86)90795-6. [DOI] [PubMed] [Google Scholar]