Skip to main content
NCBI home page
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1987 Dec;63(746):1055–1060. doi: 10.1136/pgmj.63.746.1055

Immediate versus deferred treatment for early prostatic cancer.

P H Smith 1, T G Armitage 1
PMCID: PMC2428586  PMID: 3330236

Abstract

The diagnosis of early (non-metastatic) prostatic cancer is dependent upon the patient presenting himself with symptoms or for routine rectal examination or ultrasound screening. Diagnosis in the absence of symptoms is more common outside the United Kingdom and as a result the opportunity to treat such patients occurs more commonly in other countries. The treatment options for the different stages are reviewed and the evidence for their effectiveness is considered. A review of the literature yields conflicting evidence of the efficacy of and the necessity to institute early therapy. This basic gap in our current knowledge should be filled when the results of the existing Medical Research Council (MRC) clinical trial of immediate and deferred orchidectomy are available.

Full text

PDF
1055

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bloom H. J. Prostate cancer. Radiotherapy. Recent Results Cancer Res. 1981;78:132–153. [PubMed] [Google Scholar]
  2. Byar D. P. Proceedings: The Veterans Administration Cooperative Urological Research Group's studies of cancer of the prostate. Cancer. 1973 Nov;32(5):1126–1130. doi: 10.1002/1097-0142(197311)32:5<1126::aid-cncr2820320518>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  3. Byar D. P. Treatment of prostatic cancer: studies by the Veterans Administration cooperative urological research group. Bull N Y Acad Med. 1972 Jun;48(5):751–766. [PMC free article] [PubMed] [Google Scholar]
  4. Byar D. P. VACURG studies of post-prostatectomy survival. Scand J Urol Nephrol Suppl. 1980;55:113–116. [PubMed] [Google Scholar]
  5. Correa R. J., Jr, Anderson R. G., Gibbons R. P., Mason J. T. Latent carcinoma of the prostate--why the controversy? J Urol. 1974 May;111(5):644–646. doi: 10.1016/s0022-5347(17)60036-3. [DOI] [PubMed] [Google Scholar]
  6. Elder J. S., Jewett H. J., Walsh P. C. Radical perineal prostatectomy for clinical stage B2 carcinoma of the prostate. J Urol. 1982 Apr;127(4):704–706. doi: 10.1016/s0022-5347(17)54005-7. [DOI] [PubMed] [Google Scholar]
  7. Epstein J. I., Paull G., Eggleston J. C., Walsh P. C. Prognosis of untreated stage A1 prostatic carcinoma: a study of 94 cases with extended followup. J Urol. 1986 Oct;136(4):837–839. doi: 10.1016/s0022-5347(17)45097-x. [DOI] [PubMed] [Google Scholar]
  8. Fair W. R. Hormonal therapy of advanced prostatic cancer. J Urol. 1986 Sep;136(3):653–654. doi: 10.1016/s0022-5347(17)45005-1. [DOI] [PubMed] [Google Scholar]
  9. Gibbons R. P., Correa R. J., Jr, Brannen G. E., Mason J. T. Total prostatectomy for localized prostatic cancer. J Urol. 1984 Jan;131(1):73–76. doi: 10.1016/s0022-5347(17)50210-4. [DOI] [PubMed] [Google Scholar]
  10. Harrison G. S. The prognosis of prostatic cancer in the younger man. Br J Urol. 1983 Jun;55(3):315–320. doi: 10.1111/j.1464-410x.1983.tb03307.x. [DOI] [PubMed] [Google Scholar]
  11. Paulson D. F., Hodge G. B., Jr, Hinshaw W. Radiation therapy versus delayed androgen deprivation for stage C carcinoma of the prostate. J Urol. 1984 May;131(5):901–902. doi: 10.1016/s0022-5347(17)50704-1. [DOI] [PubMed] [Google Scholar]
  12. Paulson D. F., Lin G. H., Hinshaw W., Stephani S. Radical surgery versus radiotherapy for adenocarcinoma of the prostate. J Urol. 1982 Sep;128(3):502–504. doi: 10.1016/s0022-5347(17)53016-5. [DOI] [PubMed] [Google Scholar]
  13. Smith P. H., Suciu S., Robinson M. R., Richards B., Bastable J. R., Glashan R. W., Bouffioux C., Lardennois B., Williams R. E., de Pauw M. A comparison of the effect of diethylstilbestrol with low dose estramustine phosphate in the treatment of advanced prostatic cancer: final analysis of a phase III trial of the European Organization for Research on Treatment of Cancer. J Urol. 1986 Sep;136(3):619–623. doi: 10.1016/s0022-5347(17)44995-0. [DOI] [PubMed] [Google Scholar]
  14. Walsh P. C., Mostwin J. L. Radical prostatectomy and cystoprostatectomy with preservation of potency. Results using a new nerve-sparing technique. Br J Urol. 1984 Dec;56(6):694–697. doi: 10.1111/j.1464-410x.1984.tb06149.x. [DOI] [PubMed] [Google Scholar]
  15. Wynder E. L., Mabuchi K., Whitmore W. F., Jr Epidemiology of cancer of the prostate. Cancer. 1971 Aug;28(2):344–360. doi: 10.1002/1097-0142(197108)28:2<344::aid-cncr2820280214>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES