Abstract
Total serum cholesterol and triglycerides were measured in 159 Indian patients (134 males) with acute myocardial infarction during their stay in hospital (days 1 and 2) and 3 months later in order to assess whether lipid levels measured soon after acute myocardial infarction represent basal values. Early and 3 month lipid levels were also compared according to the sex and glucose tolerance of the patients. The mean total cholesterol levels on admission (day 1) were comparable to the 3 month values in both men (6.09 +/- 0.10 vs 6.18 +/- 0.09 mmol/l) and women (6.75 +/- 0.30 vs 6.44 +/- 0.22 mmol/l) irrespective of glucose tolerance. In the entire group cholesterol levels on day 2 were significantly lower than the admission and 3 month values. Nevertheless there was a significant correlation between day 2 and 3 month values (P less than 0.0005). Serum triglyceride levels on day 2 were influenced by glucose tolerance and were significantly lower than the 3 month values in patients with normal glucose tolerance but not in patients with abnormal glucose tolerance. However there with a significant correlation between day 2 triglyceride values in patients with both normal and abnormal glucose tolerance. These results suggest that serum cholesterol measured on admission after acute myocardial infarction may be reliably used to represent basal values in both men and women irrespective of glucose tolerance. Although cholesterol and triglycerides measured on day 2 vary with either the gender or glucose tolerance of the patients, these values are still a useful guide to the patients' basal lipid state.
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Selected References
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- DODDS C., MILLS G. L. Influence of myocardial infarction on plasma-lipoprotein concentration. Lancet. 1959 Jun 6;1(7084):1160–1163. doi: 10.1016/s0140-6736(59)91178-x. [DOI] [PubMed] [Google Scholar]
- Factors influencing long-term prognosis after recovery from myocardial infarction--three-year findings of the coronary drug project. J Chronic Dis. 1974 Aug;27(6):267–285. doi: 10.1016/0021-9681(74)90091-5. [DOI] [PubMed] [Google Scholar]
- Fyfe T., Baxter R. H., Cochran K. M., Booth E. M. Plasma-lipid changes after myocardial infarction. Lancet. 1971 Nov;2(7732):997–1001. doi: 10.1016/s0140-6736(71)90322-9. [DOI] [PubMed] [Google Scholar]
- Gardner M. J., Altman D. G. Confidence intervals rather than P values: estimation rather than hypothesis testing. Br Med J (Clin Res Ed) 1986 Mar 15;292(6522):746–750. doi: 10.1136/bmj.292.6522.746. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gore J. M., Goldberg R. J., Matsumoto A. S., Castelli W. P., McNamara P. M., Dalen J. E. Validity of serum total cholesterol level obtained within 24 hours of acute myocardial infarction. Am J Cardiol. 1984 Oct 1;54(7):722–725. doi: 10.1016/s0002-9149(84)80197-6. [DOI] [PubMed] [Google Scholar]
- Jackson R., Scragg R., Marshall R., White H., O'Brien K., Small C. Changes in serum lipid concentrations during first 24 hours after myocardial infarction. Br Med J (Clin Res Ed) 1987 Jun 20;294(6587):1588–1589. doi: 10.1136/bmj.294.6587.1588. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miettinen T. A. Current views on cholesterol metabolism. Horm Metab Res. 1974;Suppl 4:37–44. [PubMed] [Google Scholar]
- Phillips G. B. Relationship between serum sex hormones and glucose, insulin and lipid abnormalities in men with myocardial infarction. Proc Natl Acad Sci U S A. 1977 Apr;74(4):1729–1733. doi: 10.1073/pnas.74.4.1729. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ryder R. E., Hayes T. M., Mulligan I. P., Kingswood J. C., Williams S., Owens D. R. How soon after myocardial infarction should plasma lipid values be assessed? Br Med J (Clin Res Ed) 1984 Dec 15;289(6459):1651–1653. doi: 10.1136/bmj.289.6459.1651. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sewdarsen M., Jialal I., Vythilingum S. Abnormal glucose tolerance and lipid abnormalities in Indian myocardial infarct survivors. S Afr Med J. 1983 Feb 12;63(7):238–240. [PubMed] [Google Scholar]
- TIBBLIN G., CRAMER K. SERUM LIPIDS DURING THE COURSE OF AN ACUTE MYOCARDIAL INFARCTION AND ONE YEAR AFTERWARDS. Acta Med Scand. 1963 Oct;174:451–455. doi: 10.1111/j.0954-6820.1963.tb07944.x. [DOI] [PubMed] [Google Scholar]
- WATSON W. C., BUCHANAN K. D., DICKSON C. SERUM CHOLESTEROL LEVELS AFTER MYOCARDIAL INFARCTION. Br Med J. 1963 Sep 21;2(5359):709–712. doi: 10.1136/bmj.2.5359.709. [DOI] [PMC free article] [PubMed] [Google Scholar]