Skip to main content
NCBI home page
Applied and Environmental Microbiology logoLink to Applied and Environmental Microbiology
. 1978 Mar;35(3):563–566. doi: 10.1128/aem.35.3.563-566.1978

Production of luteoskyrin and isolation of a new metabolite, pibasterol, from Penicillium islandicum Sopp.

A C Ghosh, A Manmade, B Kobbe, J M Townsend, A L Demain
PMCID: PMC242880  PMID: 565188

Abstract

Production of luteoskyrin, a hepatotoxin synthesized by Penicillium islandicum Sopp., was studied with various fermentation methods. Best results were obtained in static fermentations on glutinous rice at 30 degrees C. The isolated yield of pure luteoskyrin was approximately 400 mg per kg of rice. Also produced were skyrin, islandicin, iridoskyrin, rubroskyrin, chrysophanol, mannitol, and erythritol. A new metabolite, which we call pibasterol, was also isolated.

Full text

PDF
563

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bouhet J. C., Van Chuong P. P., Toma F., Kirszenbaum M., Fromageot P. Isolation and characterization of luteoskyrin and rugulosin, two hepatotoxic anthraquinonoids from Penicillium islandicum Sopp. and Penicillium rugulosum Thom. J Agric Food Chem. 1976 Sep-Oct;24(5):964–972. doi: 10.1021/jf60207a028. [DOI] [PubMed] [Google Scholar]
  2. Hesseltine C. W. Biotechnology report. Solid state fermentations. Biotechnol Bioeng. 1972 Jul;14(4):517–532. doi: 10.1002/bit.260140402. [DOI] [PubMed] [Google Scholar]
  3. Jayaraman A., Herbst E. J., Ikawa M. The bioassay of aflatoxins and related substances with Bacillus megaterium spores and chick embryos. J Am Oil Chem Soc. 1968 Oct;45(10):700–702. doi: 10.1007/BF02541261. [DOI] [PubMed] [Google Scholar]
  4. Shibata S. Some recent studies on the metabolites of fungi and lichens. Pure Appl Chem. 1973;33(1):109–128. doi: 10.1351/pac197333010109. [DOI] [PubMed] [Google Scholar]
  5. TATSUNO T., TSUKIOKA M., SAKAI Y., SUZUKI Y., ASAMI Y. Recherche sur la substance toxique du riz jauni. Pharm Bull. 1955 Dec;3(6):476–477. doi: 10.1248/cpb1953.3.476. [DOI] [PubMed] [Google Scholar]
  6. UENO I., UENO Y., TATSUNO T., URAGUCHI K. MITOCHONDRIAL RESPIRATORY IMPAIRMENT BY LUTEOSKYRIN, A HEPATOTOXIC PIGMENT OF PENICILLIUM ISLANDICUM SOPP. Jpn J Exp Med. 1964 Jun;34:135–152. [PubMed] [Google Scholar]
  7. URAGUCHI K. Isolation of two toxic agents, luteoskyrin and chlorine-containing peptide, from the metabolites of Penicillium islandicum Sopp, with some properties thereof. Jpn J Exp Med. 1961 Feb;31:19–46. [PubMed] [Google Scholar]
  8. Ueno Y., Ishikawa I. Production of luteoskyrin, a hepatotoxic pigment, by Penicillium islandicum Sopp. Appl Microbiol. 1969 Sep;18(3):406–409. doi: 10.1128/am.18.3.406-409.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Wogan G. N. Mycotoxins. Annu Rev Pharmacol. 1975;15:437–451. doi: 10.1146/annurev.pa.15.040175.002253. [DOI] [PubMed] [Google Scholar]
  10. Yamakawa H., Ueno Y. Microbial assay of hepatotoxic anthraquinones with Escherichia coli F-11. Chem Pharm Bull (Tokyo) 1970 Jan;18(1):177–181. doi: 10.1248/cpb.18.177. [DOI] [PubMed] [Google Scholar]

Articles from Applied and Environmental Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES