Abstract
We report the development of the carpal tunnel syndrome in 3 hypertensive men (aged 46-58) treated with beta-blockers (propranolol in two patients and metoprolol in the 3rd) for 8-11 years. Known causes of carpal tunnel syndrome were excluded in each case. Withdrawal of the beta-blocker was followed by complete resolution of symptoms and signs after a period of 8-10 weeks. No evidence of recurrence could be detected during follow-up of 7-18 months. The possible mechanisms of drug-induced carpal tunnel syndrome are briefly discussed.
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Selected References
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- Amadio P. C. Pyridoxine as an adjunct in the treatment of carpal tunnel syndrome. J Hand Surg Am. 1985 Mar;10(2):237–241. doi: 10.1016/s0363-5023(85)80112-x. [DOI] [PubMed] [Google Scholar]
- Dekel S., Papaioannou T., Rushworth G., Coates R. Idiopathic carpal tunnel syndrome caused by carpal stenosis. Br Med J. 1980 May 31;280(6227):1297–1299. doi: 10.1136/bmj.280.6227.1297. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dorwart B. B. Carpal tunnel syndrome: a review. Semin Arthritis Rheum. 1984 Nov;14(2):134–140. doi: 10.1016/0049-0172(84)90003-9. [DOI] [PubMed] [Google Scholar]
- Ellis J. M., Folkers K., Levy M., Shizukuishi S., Lewandowski J., Nishii S., Schubert H. A., Ulrich R. Response of vitamin B-6 deficiency and the carpal tunnel syndrome to pyridoxine. Proc Natl Acad Sci U S A. 1982 Dec;79(23):7494–7498. doi: 10.1073/pnas.79.23.7494. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ellis J., Folkers K., Watanabe T., Kaji M., Saji S., Caldwell J. W., Temple C. A., Wood F. S. Clinical results of a cross-over treatment with pyridoxine and placebo of the carpal tunnel syndrome. Am J Clin Nutr. 1979 Oct;32(10):2040–2046. doi: 10.1093/ajcn/32.10.2040. [DOI] [PubMed] [Google Scholar]
- Harrison W., Stewart J., Lovelace R., Quitkin F. Case report of carpal tunnel syndrome associated with tranylcypromine. Am J Psychiatry. 1983 Sep;140(9):1229–1230. doi: 10.1176/ajp.140.9.1229. [DOI] [PubMed] [Google Scholar]
- Upton A. R., McComas A. J. The double crush in nerve entrapment syndromes. Lancet. 1973 Aug 18;2(7825):359–362. doi: 10.1016/s0140-6736(73)93196-6. [DOI] [PubMed] [Google Scholar]