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. 1988 Jun;64(752):426–430. doi: 10.1136/pgmj.64.752.426

Serious complications following treatment of chronic idiopathic thrombocytopenic purpura.

W Wanachiwanawin 1, S Visudhiphan 1, A Piankijagum 1, S Vatanavicharn 1
PMCID: PMC2428857  PMID: 3211819

Abstract

Six patients had serious complications as consequences of treatment of idiopathic thrombocytopenic purpura. Five had splenectomy-related complications, one of them developed fatal intra-abdominal bleeding. Three patients acquired operation-related serious infection, two of them died. Serious neutropenia after vinblastine-loaded platelets occurred in one patient leading to pseudomonas septicaemia and panophthalmitis with permanent vision loss of left eye. Recurrence thrombocytopenia occurred in every case during serious complications. Early detection by awareness of the possibility of serious complications can reduce morbidity and mortality occurring after therapy of idiopathic thrombocytopenic purpura.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahn Y. S., Byrnes J. J., Harrington W. J., Cayer M. L., Smith D. S., Brunskill D. E., Pall L. M. The treatment of idiopathic thrombocytopenia with vinblastine-loaded platelets. N Engl J Med. 1978 May 18;298(20):1101–1107. doi: 10.1056/NEJM197805182982001. [DOI] [PubMed] [Google Scholar]
  2. Ahn Y. S., Harrington W. J., Simon S. R., Mylvaganam R., Pall L. M., So A. G. Danazol for the treatment of idiopathic thrombocytopenic purpura. N Engl J Med. 1983 Jun 9;308(23):1396–1399. doi: 10.1056/NEJM198306093082306. [DOI] [PubMed] [Google Scholar]
  3. Ahn Y. S., Harrington W. J. Treatment of idiopathic thrombocytopenic purpura (ITP). Annu Rev Med. 1977;28:299–309ENG. doi: 10.1146/annurev.me.28.020177.001503. [DOI] [PubMed] [Google Scholar]
  4. Block G. E., Evans R., Zajtchuk R. Splenectomy for idiopathic thrombocytopenic purpura. Arch Surg. 1966 Apr;92(4):484–489. doi: 10.1001/archsurg.1966.01320220040006. [DOI] [PubMed] [Google Scholar]
  5. Burns T. R., Saleem A. Idiopathic thrombocytopenic purpura. Am J Med. 1983 Dec;75(6):1001–1007. doi: 10.1016/0002-9343(83)90881-1. [DOI] [PubMed] [Google Scholar]
  6. DiFino S. M., Lachant N. A., Kirshner J. J., Gottlieb A. J. Adult idiopathic thrombocytopenic purpura. Clinical findings and response to therapy. Am J Med. 1980 Sep;69(3):430–442. doi: 10.1016/0002-9343(80)90016-9. [DOI] [PubMed] [Google Scholar]
  7. Karpatkin S. Autoimmune thrombocytopenic purpura. Semin Hematol. 1985 Oct;22(4):260–288. [PubMed] [Google Scholar]
  8. Karpatkin S. Autoimmune thrombocytopenic purpura. Blood. 1980 Sep;56(3):329–343. [PubMed] [Google Scholar]
  9. McMillan R. Chronic idiopathic thrombocytopenic purpura. N Engl J Med. 1981 May 7;304(19):1135–1147. doi: 10.1056/NEJM198105073041904. [DOI] [PubMed] [Google Scholar]
  10. Rosse W. F. Treatment of chronic immune thrombocytopenia. Clin Haematol. 1983 Feb;12(1):267–284. [PubMed] [Google Scholar]
  11. Sukenik S., el-Roeiy A., Shoenfeld Y. Lupus anticoagulant and anticardiolipin antibodies in systemic lupus erythematosus. Acta Haematol. 1986;76(2-3):86–89. doi: 10.1159/000206027. [DOI] [PubMed] [Google Scholar]

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