Abstract
The biocidal and biostatic activities of seven glycol monoalkyl ether compounds were evaluated as part of an effort to find an improved anti-icing additive for jet aircraft fuel. Typical fuel contaminants, Cladosporium resinae, Gliomastix sp., Candida sp., Pseudomonas aeruginosa, and a mixed culture containing sulfate-reducing bacteria were used as assay organisms. Studies were carried out over 3 to 4 months in two-phase systems containing jet fuel and aqueous media. Diethylene glycol monomethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, and 2-methoxyethanol were generally biocidal in aqueous concentrations of 10 to 17% for all organisms except Gliomastix, which required 25% or more. 2-Ethoxyethanol, 2-propoxyethanol, and 2-butoxyethanol were biocidal at progressively lower concentrations down to 1 to 2% for 2-butoxyethanol. The enhanced antimicrobial activity of these three compounds was attributed to cytoplasmic membrane damage because of the correlation between surface tension measurements and lytic activity with P. aeruginosa cells. The mechanism of action of the less active compounds appeared to be due to osmotic (dehydrating) effects. When all requirements are taken into account, diethylene glycol monomethyl ether appears to be the most promising replacement for the currently used additive, 2-methoxyethanol.
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- BERRY H., MICHAELS I. The evaluation of the bactericidal activity of ethylene glycol and some of its monoalkyl ethers against Bacterium coli. J Pharm Pharmacol. 1950 Feb;2(2):105–114. [PubMed] [Google Scholar]
- Bushnell L. D., Haas H. F. The Utilization of Certain Hydrocarbons by Microorganisms. J Bacteriol. 1941 May;41(5):653–673. doi: 10.1128/jb.41.5.653-673.1941. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cox C. S. Bacterial survival in suspension in polyethylene glycol solutions. J Gen Microbiol. 1966 Nov;45(2):275–281. doi: 10.1099/00221287-45-2-275. [DOI] [PubMed] [Google Scholar]
- Godson G. N., Sinsheimer R. L. Use of Brij lysis as a general method to prepare polyribosomes from Escherichia coli. Biochim Biophys Acta. 1967 Dec 19;149(2):489–495. doi: 10.1016/0005-2787(67)90176-1. [DOI] [PubMed] [Google Scholar]
- Haines J. R., Alexander M. Microbial degradation of polyethylene glycols. Appl Microbiol. 1975 May;29(5):621–625. doi: 10.1128/am.29.5.621-625.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Höhne C., Patsch R. Glykoläther als Lösungsvermittler bei Resistenzbestimmungen. Zentralbl Bakteriol Orig. 1969;211(1):81–87. [PubMed] [Google Scholar]
- SISLER F. D., ZOBELL C. E. Hydrogen-utilizing, sulfate-reducing bacteria in marine sediments. J Bacteriol. 1950 Dec;60(6):747–756. doi: 10.1128/jb.60.6.747-756.1950. [DOI] [PMC free article] [PubMed] [Google Scholar]