Abstract
A 22 year old woman was admitted with amitriptyline overdose. Twenty six hours later she developed acute myocardial infarction. Cardiotoxic effects of tricyclic antidepressants are discussed and the importance of considering myocardial infarction as a complication of tricyclic antidepressant overdose is emphasized.
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Selected References
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- Barnes R. J., Kong S. M., Wu R. W. Electrocardiographic changes in amitriptyline poisoning. Br Med J. 1968 Jul 27;3(5612):222–223. doi: 10.1136/bmj.3.5612.222. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Benowitz N. L., Rosenberg J., Becker C. E. Cardiopulmonary catastrophes in drug-overdosed patients. Med Clin North Am. 1979 Jan;63(1):267–296. doi: 10.1016/s0025-7125(16)31728-x. [DOI] [PubMed] [Google Scholar]
- Cheitlin M. D., McAllister H. A., de Castro C. M. Myocardial infarction without atherosclerosis. JAMA. 1975 Mar 3;231(9):951–959. [PubMed] [Google Scholar]
- Jefferson J. W. A review of the cardiovascular effects and toxicity of tricyclic antidepressants. Psychosom Med. 1975 Mar-Apr;37(2):160–179. doi: 10.1097/00006842-197503000-00006. [DOI] [PubMed] [Google Scholar]
- Langou R. A., Van Dyke C., Tahan S. R., Cohen L. S. Cardiovascular manifestations of tricyclic antidepressant overdose. Am Heart J. 1980 Oct;100(4):458–464. doi: 10.1016/0002-8703(80)90657-2. [DOI] [PubMed] [Google Scholar]
- Langslet A., Johansen W. G., Ryg M., Skomedal T., Oye I. Effects of dibenzepine and imipramine on the isolated rat heart. Eur J Pharmacol. 1971 May;14(4):333–339. doi: 10.1016/0014-2999(71)90186-5. [DOI] [PubMed] [Google Scholar]
- Marshall J. B., Forker A. D. Cardiovascular effects of tricyclic antidepressant drugs: therapeutic usage, overdose, and management of complications. Am Heart J. 1982 Mar;103(3):401–414. doi: 10.1016/0002-8703(82)90281-2. [DOI] [PubMed] [Google Scholar]
- Maseri A., L'Abbate A., Baroldi G., Chierchia S., Marzilli M., Ballestra A. M., Severi S., Parodi O., Biagini A., Distante A. Coronary vasospasm as a possible cause of myocardial infarction. A conclusion derived from the study of "preinfarction" angina. N Engl J Med. 1978 Dec 7;299(23):1271–1277. doi: 10.1056/NEJM197812072992303. [DOI] [PubMed] [Google Scholar]
- Rudorfer M. V. Cardiovascular changes and plasma drug levels after amitriptyline overdose. J Toxicol Clin Toxicol. 1982 Mar;19(1):67–78. doi: 10.3109/15563658208990367. [DOI] [PubMed] [Google Scholar]
- SIGG E. B., OSBORNE M., KOROL B. CARDIOVASCULAR EFFECTS OF IMIPRAMINE. J Pharmacol Exp Ther. 1963 Aug;141:237–243. [PubMed] [Google Scholar]
- SLOMAN L. Myocardial infarction during imipramine treatment of depression. Can Med Assoc J. 1960 Jan 2;82:20–22. [PMC free article] [PubMed] [Google Scholar]
- Silverman G. Cardiotoxicity of amitriptyline. Lancet. 1972 Sep 30;2(7779):710–711. doi: 10.1016/s0140-6736(72)92117-4. [DOI] [PubMed] [Google Scholar]
- Smith D. B., Tyznik J. W. Desipramine-induced conduction disorder mimicking myocardial infarction. Postgrad Med. 1987 Sep 15;82(4):86–88. doi: 10.1080/00325481.1987.11699975. [DOI] [PubMed] [Google Scholar]
- Thorstrand C. Clinical features in poisonings by tricyclic antidepressants with special reference to the ECG. Acta Med Scand. 1976;199(5):337–344. doi: 10.1111/j.0954-6820.1976.tb06745.x. [DOI] [PubMed] [Google Scholar]
