Abstract
A fatal case of acetonitrile ingestion is reported. The patient presented having apparently taken an overdose but was well until around 24 hours after the supposed ingestion, when cardiovascular collapse and profound metabolic acidosis developed. Later investigation revealed that the patient had taken acetone and acetonitrile. Acetone is known to slow the metabolism of acetonitrile to cyanide, thereby delaying the appearance of toxicity.
Full text
PDF

Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- AMDUR M. L. Accidental group exposure to acetonitrile--a clinical study. J Occup Med. 1959 Dec;1:627–633. doi: 10.1097/00043764-195912000-00002. [DOI] [PubMed] [Google Scholar]
- Caravati E. M., Litovitz T. L. Pediatric cyanide intoxication and death from an acetonitrile-containing cosmetic. JAMA. 1988 Dec 16;260(23):3470–3473. [PubMed] [Google Scholar]
- Dequidt J., Furon D., Wattle F., Haguenoer J. M., Scherpereel P., Gosselin B., Ginestet A. Les intoxications par l'acétonitrile à propos d'un cas mortel. Eur J Toxicol Environ Hyg. 1974 Mar-Apr;7(2):91–97. [PubMed] [Google Scholar]
- Freeman J. J., Hayes E. P. Acetone potentiation of acute acetonitrile toxicity in rats. J Toxicol Environ Health. 1985;15(5):609–621. doi: 10.1080/15287398509530690. [DOI] [PubMed] [Google Scholar]
- Jaeger A., Tempe J. D., Porte A., Stoeckel L., Mantz J. M. Acute volontary intoxication by acetonitrile. Acta Pharmacol Toxicol (Copenh) 1977;41 (Suppl 2):340–340. [PubMed] [Google Scholar]
- Willhite C. C. Inhalation toxicology of acute exposure to aliphatic nitriles. Clin Toxicol. 1981 Aug;18(8):991–1003. doi: 10.3109/15563658108990329. [DOI] [PubMed] [Google Scholar]
