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. 1990 Mar;66(773):205–209. doi: 10.1136/pgmj.66.773.205

A study of serum zinc, albumin, alpha-2-macroglobulin and transferrin levels in acute and long stay elderly hospital patients.

G M Craig 1, S J Evans 1, B J Brayshaw 1, S K Raina 1
PMCID: PMC2429465  PMID: 1694579

Abstract

Serum zinc levels measured by atomic absorption spectrophotometry were found to be low (less than 10.5 mumols/l) in 38% of acute geriatric admissions, 69% of long stay geriatric patients and 19% of a control group of elderly hospital patients with a normal serum albumin. There was a significant positive correlation between serum zinc and serum albumin in all groups. In acutely ill geriatric patients only, there was a weak but statistically significant positive correlation between serum zinc and alpha-2-macroglobulin (A2M) (r = 0.20), P less than 0.05). Serum transferrin was low in 46% of acute geriatric patients and 22% of long stay geriatric patients but there was no correlation between serum zinc and serum transferrin levels in any patient group. There were significant differences in serum zinc, A2M and transferrin levels between the acute and long stay geriatric patients. The differences in serum zinc levels between these patients groups could not be explained by changes in serum A2M, transferrin or albumin. Changes mediated by an acute phase response may have influenced results in the acute geriatric group of patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bates J., McClain C. J. The effect of severe zinc deficiency on serum levels of albumin, transferrin, and prealbumin in man. Am J Clin Nutr. 1981 Sep;34(9):1655–1660. doi: 10.1093/ajcn/34.9.1655. [DOI] [PubMed] [Google Scholar]
  2. Büchler M., Malfertheiner P., Schoetensack C., Uhl W., Beger H. G. Sensitivity of antiproteases, complement factors and C-reactive protein in detecting pancreatic necrosis. Results of a prospective clinical study. Int J Pancreatol. 1986 Oct;1(3-4):227–235. doi: 10.1007/BF02795248. [DOI] [PubMed] [Google Scholar]
  3. Chesters J. K., Will M. Zinc transport proteins in plasma. Br J Nutr. 1981 Jul;46(1):111–118. doi: 10.1079/bjn19810014. [DOI] [PubMed] [Google Scholar]
  4. Dinarello C. A. An update on human interleukin-1: from molecular biology to clinical relevance. J Clin Immunol. 1985 Sep;5(5):287–297. doi: 10.1007/BF00918247. [DOI] [PubMed] [Google Scholar]
  5. Flint D. M., Wahlqvist M. L., Smith T. J., Parish A. E. Zinc and protein status in the elderly. J Hum Nutr. 1981 Aug;35(4):287–295. doi: 10.3109/09637488109143055. [DOI] [PubMed] [Google Scholar]
  6. Foote J. W., Delves H. T. Albumin bound and alpha 2-macroglobulin bound zinc concentrations in the sera of healthy adults. J Clin Pathol. 1984 Sep;37(9):1050–1054. doi: 10.1136/jcp.37.9.1050. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gehring M. R., Shiels B. R., Northemann W., de Bruijn M. H., Kan C. C., Chain A. C., Noonan D. J., Fey G. H. Sequence of rat liver alpha 2-macroglobulin and acute phase control of its messenger RNA. J Biol Chem. 1987 Jan 5;262(1):446–454. [PubMed] [Google Scholar]
  8. Haider M., Haider S. Q. Assessment of protein-calorie malnutrition. Clin Chem. 1984 Aug;30(8):1286–1299. [PubMed] [Google Scholar]
  9. Hsu J. M., Anthony W. L., Buchanan P. J. Zinc deficiency and incorporation of 14C-labeled methionine into tissue proteins in rats. J Nutr. 1969 Dec;99(4):425–432. doi: 10.1093/jn/99.4.425. [DOI] [PubMed] [Google Scholar]
  10. Jackson M. J., Jones D. A., Edwards R. H. Tissue zinc levels as an index of body zinc status. Clin Physiol. 1982 Aug;2(4):333–343. doi: 10.1111/j.1475-097x.1982.tb00038.x. [DOI] [PubMed] [Google Scholar]
  11. Lindeman R. D., Bottomley R. G., Cornelison R. L., Jr, Jacobs L. A. Influence of acute tissue injury on zinc metabolism in man. J Lab Clin Med. 1972 Mar;79(3):452–460. [PubMed] [Google Scholar]
  12. McBean L. D., Smith J. C., Jr, Berne B. H., Halsted J. A. Serum zinc and alpha2-macroglobulin concentration in myocardial infarction, decubitus ulcer, multiple myeloma, prostatic carcinoma, Down's syndrome and nephrotic syndrome. Clin Chim Acta. 1974 Jan 19;50(1):43–51. doi: 10.1016/0009-8981(74)90076-x. [DOI] [PubMed] [Google Scholar]
  13. Powanda M. C. Changes in body balances of nitrogen and other key nutrients: description and underlying mechanisms. Am J Clin Nutr. 1977 Aug;30(8):1254–1268. doi: 10.1093/ajcn/30.8.1254. [DOI] [PubMed] [Google Scholar]
  14. Prasad A. S. Clinical, endocrinological and biochemical effects of zinc deficiency. Clin Endocrinol Metab. 1985 Aug;14(3):567–589. doi: 10.1016/s0300-595x(85)80007-4. [DOI] [PubMed] [Google Scholar]
  15. Prasad A. S. Discovery and importance of zinc in human nutrition. Fed Proc. 1984 Oct;43(13):2829–2834. [PubMed] [Google Scholar]
  16. Prasad A. S., Oberleas D. Thymidine kinase activity and incorporation of thymidine into DNA in zinc-deficient tissue. J Lab Clin Med. 1974 Apr;83(4):634–639. [PubMed] [Google Scholar]
  17. Roberts R. C. Protease inhibitors of human plasma. Alpha-2-macroglobulin. J Med. 1985;16(1-3):129–224. [PubMed] [Google Scholar]
  18. Sandstead H. H., Henriksen L. K., Greger J. L., Prasad A. S., Good R. A. Zinc nutriture in the elderly in relation to taste acuity, immune response, and wound healing. Am J Clin Nutr. 1982 Nov;36(5 Suppl):1046–1059. doi: 10.1093/ajcn/36.5.1046. [DOI] [PubMed] [Google Scholar]
  19. Senapati A., Jenner G., Thompson R. P. Zinc in the elderly. Q J Med. 1989 Jan;70(261):81–87. [PubMed] [Google Scholar]
  20. Stafford W., Smith R. G., Lewis S. J., Henery E., Stephen P. J., Rafferty J., Simpson G. K., Bell P. C., O'Rorke K. A study of zinc status of elderly institutionalized patients. Age Ageing. 1988 Jan;17(1):42–48. doi: 10.1093/ageing/17.1.42. [DOI] [PubMed] [Google Scholar]
  21. Stuart J., Lewis S. M. Monitoring the acute phase response. BMJ. 1988 Nov 5;297(6657):1143–1144. doi: 10.1136/bmj.297.6657.1143. [DOI] [PMC free article] [PubMed] [Google Scholar]

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