Abstract
A case of skin necrosis at the sites of injection of subcutaneous heparin is described. The patient went on to develop heparin-induced thrombocytopenia and pulmonary embolism. Review of the previously described cases of heparin-associated skin necrosis reveals that this sequence of events is not uncommon.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barber F. A., Burton W. C., Guyer R. The heparin-induced thrombocytopenia and thrombosis syndrome. Report of a case. J Bone Joint Surg Am. 1987 Jul;69(6):935–937. [PubMed] [Google Scholar]
- Chong B. H., Castaldi P. A. Heparin-induced thrombocytopenia: further studies of the effects of heparin-dependent antibodies on platelets. Br J Haematol. 1986 Oct;64(2):347–354. doi: 10.1111/j.1365-2141.1986.tb04128.x. [DOI] [PubMed] [Google Scholar]
- Hall J. C., McConahay D., Gibson D., Crockett J., Conn R. Heparin necrosis. An anticoagulation syndrome. JAMA. 1980 Oct 17;244(16):1831–1832. [PubMed] [Google Scholar]
- Jackson A. M., Pollock A. V. Skin necrosis after heparin injection. Br Med J (Clin Res Ed) 1981 Oct 24;283(6299):1087–1088. doi: 10.1136/bmj.283.6299.1087-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- King D. J., Kelton J. G. Heparin-associated thrombocytopenia. Ann Intern Med. 1984 Apr;100(4):535–540. doi: 10.7326/0003-4819-100-4-535. [DOI] [PubMed] [Google Scholar]
- Lim K. B., Tan T. Skin necrosis as a complication of improperly administered subcutaneous heparin. Singapore Med J. 1986 Aug;27(4):356–357. [PubMed] [Google Scholar]
- Ulrick P. J., Manoharan A. Heparin-induced skin reaction. Med J Aust. 1984 Mar 3;140(5):287–289. doi: 10.5694/j.1326-5377.1984.tb104041.x. [DOI] [PubMed] [Google Scholar]
- White P. W., Sadd J. R., Nensel R. E. Thrombotic complications of heparin therapy: including six cases of heparin--induced skin necrosis. Ann Surg. 1979 Nov;190(5):595–608. doi: 10.1097/00000658-197911000-00007. [DOI] [PMC free article] [PubMed] [Google Scholar]