Abstract
Two patients with long-standing chronic bronchial suppuration developed antineutrophil cytoplasmic antibody (ANCA) positive Wegener's granulomatosis and microscopic polyarteritis respectively. There is published evidence of an association between previous suppurative respiratory disease and Wegener's granulomatosis. We believe that our cases provide further evidence that chronic lung infection may play an aetiological role in the development of ANCA-positive systemic necrotizing vasculitis in some individuals.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Butland R. J., Cole P., Citron K. M., Turner-Warwick M. Chronic bronchial suppuration and inflammatory bowel disease. Q J Med. 1981;50(197):63–75. [PubMed] [Google Scholar]
- Leaker B., Cambridge G. Anti-neutrophil cytoplasmic antibodies and vasculitis. Postgrad Med J. 1990 Feb;66(772):77–79. doi: 10.1136/pgmj.66.772.77. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mathieu J. P., Stack B. H., Dick W. C., Buchanan W. W. Pulmonary infection and rheumatoid arthritis. Br J Dis Chest. 1978 Jan;72(1):57–61. doi: 10.1016/0007-0971(78)90007-4. [DOI] [PubMed] [Google Scholar]
- Pinching A. J., Lockwood C. M., Pussell B. A., Rees A. J., Sweny P., Evans D. J., Bowley N., Peters D. K. Wegener's granulomatosis: observations on 18 patients with severe renal disease. Q J Med. 1983 Autumn;52(208):435–460. [PubMed] [Google Scholar]
- Pinching A. J., Rees A. J., Pussell B. A., Lockwood C. M., Mitchison R. S., Peters D. K. Relapses in Wegener's granulomatosis: the role of infection. Br Med J. 1980 Sep 27;281(6244):836–838. doi: 10.1136/bmj.281.6244.836. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROSE G. A., SPENCER H. Polyarteritis nodosa. Q J Med. 1957 Jan;26(101):43–81. [PubMed] [Google Scholar]
- Savage C. O., Winearls C. G., Evans D. J., Rees A. J., Lockwood C. M. Microscopic polyarteritis: presentation, pathology and prognosis. Q J Med. 1985 Aug;56(220):467–483. [PubMed] [Google Scholar]
- Walker W. C. Pulmonary infections and rheumatoid arthritis. Q J Med. 1967 Apr;36(142):239–251. [PubMed] [Google Scholar]
