Abstract
A 33 year old man developed fever, malaise, jaundice, pancytopenia, coagulation abnormalities, hepatomegaly, pleural effusions and a subcutaneous lump. Biopsies revealed a lobular panniculitis with the presence of cytophagic histiocytes; erythrophagocytosis was also demonstrated in the liver and bone marrow. Despite the use of chemotherapy (CHOP) his clinical condition deteriorated and he died 5 months after presentation. This illness is consistent with the recently described syndrome of histiocytic cytophagic panniculitis.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barron D. R., Davis B. R., Pomeranz J. R., Hines J. D., Park C. H. Cytophagic histiocytic panniculitis. A variant of malignant histiocytosis. Cancer. 1985 Jun 1;55(11):2538–2542. doi: 10.1002/1097-0142(19850601)55:11<2538::aid-cncr2820551104>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
- Ducatman B. S., Wick M. R., Morgan T. W., Banks P. M., Pierre R. V. Malignant histiocytosis: a clinical, histologic, and immunohistochemical study of 20 cases. Hum Pathol. 1984 Apr;15(4):368–377. doi: 10.1016/s0046-8177(84)80036-2. [DOI] [PubMed] [Google Scholar]
- Isaacson P. G. Histiocytic malignancy. Histopathology. 1985 Sep;9(9):1007–1011. doi: 10.1111/j.1365-2559.1985.tb02885.x. [DOI] [PubMed] [Google Scholar]
- Jaffe E. S., Costa J., Fauci A. S., Cossman J., Tsokos M. Malignant lymphoma and erythrophagocytosis simulating malignant histiocytosis. Am J Med. 1983 Nov;75(5):741–749. doi: 10.1016/0002-9343(83)90402-3. [DOI] [PubMed] [Google Scholar]
- Ladisch S., Poplack D. G., Holiman B., Blaese R. M. Immunodeficiency in familial erythrophagocytic lymphohistiocytosis. Lancet. 1978 Mar 18;1(8064):581–583. doi: 10.1016/s0140-6736(78)91028-0. [DOI] [PubMed] [Google Scholar]
- March L. M., Webb J., Eckstein R. P. Cytophagic panniculitis. Aust N Z J Med. 1986 Jun;16(3):397–401. doi: 10.1111/j.1445-5994.1986.tb01197.x. [DOI] [PubMed] [Google Scholar]
- Maury C. P., Pettersson T. Detection of circulating tumour necrosis factor in systemic histiocytosis. Br J Haematol. 1989 Feb;71(2):293–295. doi: 10.1111/j.1365-2141.1989.tb04271.x. [DOI] [PubMed] [Google Scholar]
- Pileri S., Mazza P., Rivano M. T., Martinelli G., Cavazzini G., Gobbi M., Taruscio D., Lauria F., Tura S. Malignant histiocytosis (true histiocytic lymphoma) clinicopathological study of 25 cases. Histopathology. 1985 Sep;9(9):905–920. doi: 10.1111/j.1365-2559.1985.tb02877.x. [DOI] [PubMed] [Google Scholar]
- Risdall R. J., McKenna R. W., Nesbit M. E., Krivit W., Balfour H. H., Jr, Simmons R. L., Brunning R. D. Virus-associated hemophagocytic syndrome: a benign histiocytic proliferation distinct from malignant histiocytosis. Cancer. 1979 Sep;44(3):993–1002. doi: 10.1002/1097-0142(197909)44:3<993::aid-cncr2820440329>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
- Su I. J., Hsieh H. J., Lee C. Y. Histiocytic medullary reticulosis: a lethal form of primary EBV infection in young children in Taiwan. Lancet. 1989 Feb 18;1(8634):389–389. doi: 10.1016/s0140-6736(89)91768-6. [DOI] [PubMed] [Google Scholar]
- Willis S. M., Opal S. M., Fitzpatrick J. E. Cytophagic histiocytic panniculitis. Systemic histiocytosis presenting as chronic, nonhealing, ulcerative skin lesions. Arch Dermatol. 1985 Jul;121(7):910–913. doi: 10.1001/archderm.121.7.910. [DOI] [PubMed] [Google Scholar]
- Winkelmann R. K., Bowie E. J. Hemorrhagic diathesis associated with benign histiocytic, cytophagic panniculitis and systemic histiocytosis. Arch Intern Med. 1980 Nov;140(11):1460–1463. [PubMed] [Google Scholar]