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. 1978 Jun;35(6):1074–1078. doi: 10.1128/aem.35.6.1074-1078.1978

Production of cyclochlorotine and a new metabolite, simatoxin, by Penicillium islandicum Sopp.

A C Ghosh, A Manmade, J M Townsend, A Bousquet, J F Howes, A L Demain
PMCID: PMC242987  PMID: 677874

Abstract

Production of the hepatotoxin cyclochlorotine by Penicillium islandicum was studied under a variety of fermentation conditions. The best system for production was agitated red wheat. A thin-layer chromatographic method was developed for the detection of this cyclic polypeptide. These experiments have resulted in the isolation of a new toxic metabolite, which we call simatoxin.

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Selected References

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