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. 1978 Jul;36(1):63–67. doi: 10.1128/aem.36.1.63-67.1978

Microbial and chemical transformations of some 12,13-epoxytrichothec-9,10-enes.

C A Claridge, H Schmitz
PMCID: PMC243035  PMID: 100053

Abstract

Resting cells of Streptomyces griseus, Mucor mucedo, and a growing culture of Acinetobacter calcoaceticus when mixed with compounds related to 12,13-epoxytrichothec-9-ene-4beta,15-diacetoxy-3alpha-ol(anguidine) produced a series of derivatives that were either partially hydrolyzed or selectively acylated. These derivatives showed marked differences in activities as assayed by antifungal and tissue culture cytotoxicity tests.

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Selected References

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  1. Ciegler A. Mycotoxins: occurrence, chemistry, biological activity. Lloydia. 1975 Jan-Feb;38(1):21–35. [PubMed] [Google Scholar]
  2. Ellison R. A., Kotsonis F. N. In vitro metabolism of T-2 toxin. Appl Microbiol. 1974 Feb;27(2):423–424. doi: 10.1128/am.27.2.423-424.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Grove J. F., Mortimer P. H. The cytotoxicity of some transformation products of diacetoxyscirpenol. Biochem Pharmacol. 1969 Jun;18(6):1473–1478. doi: 10.1016/0006-2952(69)90261-5. [DOI] [PubMed] [Google Scholar]
  4. HORVATH I., VARGA J. M. Enzymic inactivation of trichothecin and crotocin. Nature. 1961 Oct 7;192:88–88. doi: 10.1038/192088a0. [DOI] [PubMed] [Google Scholar]
  5. Jones K. L. FRESH ISOLATES OF ACTINOMYCETES IN WHICH THE PRESENCE OF SPOROGENOUS AERIAL MYCELIA IS A FLUCTUATING CHARACTERISTIC. J Bacteriol. 1949 Feb;57(2):141–145. doi: 10.1128/jb.57.2.141-145.1949. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Yoshizawa T., Morooka N. Biological modification of trichothecene mycotoxins: acetylation and deacetylation of deoxynivalenols by Fusarium spp. Appl Microbiol. 1975 Jan;29(1):54–58. doi: 10.1128/am.29.1.54-58.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Yoshizawa T., Morooka N. Comparative studies on microbial and chemical modifications of trichothecene mycotoxins. Appl Microbiol. 1975 Jul;30(1):38–43. doi: 10.1128/am.30.1.38-43.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]

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