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. 1978 Sep;36(3):445–449. doi: 10.1128/aem.36.3.445-449.1978

Endotoxins in commercial vaccines.

M R Geier, H Stanbro, C R Merril
PMCID: PMC243067  PMID: 727776

Abstract

Twenty samples of commercial vaccines intended for administration to humans were assayed for the presence of bacterial endotoxins by using the Limulus amebocyte lysate test. Sixteen of the vaccines contained more than 0.1 ng of endotoxin per ml (which corresponds to 103 bacterial cell wall equivalents per ml in the undiluted vaccines). These results suggest that at some stage of preparation, the vaccines have contained varying amounts of gram-negative bacteria and may indicate the presence of other bacterial products as well. It might be useful to list the level of endotoxins, phage, and other contaminants on each vaccine lot to facilitate studies on any side effects of these contaminants. Selection of vaccine lots with the least endotoxin might reduce some of the adverse effects of vaccinations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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