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. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: Pain. 2007 Aug 7;136(1-2):75–84. doi: 10.1016/j.pain.2007.06.017

Fig. 3. Tolerance to the hyperalgesic effect of LPS in adrenalectomized and sham-operated mice.

Fig. 3

Data represent the mean change in grip force responses from their original control values prior to each injection of LPS (mean ± SEM) 24 hr after each of 4 weekly s.c. injections of either 5 mg/kg of LPS or saline in the same adrenalectomized (ADX) and sham-operated mice as in figure 2A. Asterisks represent significant decreases (P < 0.05) in the responses following the injection of LPS in each of the two groups injected with LPS compared to those injected with saline, as determined using ANOVA followed by PLSD. By the second week of injections, tolerance to the effect of LPS was evident by the lack of significant decreases in grip force following LPS.