Skip to main content
Applied and Environmental Microbiology logoLink to Applied and Environmental Microbiology
. 1978 Oct;36(4):552–554. doi: 10.1128/aem.36.4.552-554.1978

Production of xanthomegnin and viomellein by isolates of Aspergillus ochraceus, Penicillium cyclopium, and Penicillium viridicatum.

M E Stack, P B Mislivec
PMCID: PMC243090  PMID: 708029

Abstract

Fungal isolates from legumes were cultured on rice and examined for production of the toxic mold metabolites xanthomegnin and viomellein. Six of 14 Aspergillus ochraceus isolates produced from 0.3 to 1.3 mg of xanthomegnin per g and 0.1 to 1.0 mg of viomellein per g. One of nine isolates of Penicillium cyclopium produced 0.1 mg of xanthomegnin per g and 0.06 mg of viomellein per g. Three of nine P. viridicatum isolates produced from 0.4 to 1.6 mg of xanthomegnin per g and 0.2 to 0.4 mg of viomellein per g. This is the first report of xanthomegnin and viomellein production by A. ochraeus and P. cyclopium.

Full text

PDF
552

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLANK F., DAY W. C., JUST G. Metabolites of pathogenic fungi. II. The isolation of xanthomegnin from Trichophyton megnini Blanchard 1896. J Invest Dermatol. 1963 Mar;40:133–137. [PubMed] [Google Scholar]
  2. Barnes J. M., Austwick P. K., Carter R. L., Flynn F. V., Peristianis G. C., Aldridge W. N. Balkan (endemic) nephropathy and a toxin-producing strain of Penicillium verrucosum var cyclopium: An experimental model in rats. Lancet. 1977 Mar 26;1(8013):671–675. doi: 10.1016/S0140-6736(77)92115-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Budiarso I. T., Carlton W. W., Tuite J. F. Phototoxic syndrome induced in mice by rice cultures of Penicillium viridicatum and exposure to sunlight. Pathol Vet. 1970;7(6):531–546. doi: 10.1177/030098587000700608. [DOI] [PubMed] [Google Scholar]
  4. Carlton W. W., Stack M. E., Eppley R. M. Hepatic alterations produced in mice by xanthomegnin and viomellein, metabolites of Penicillium viridicatum. Toxicol Appl Pharmacol. 1976 Nov;38(2):455–459. doi: 10.1016/0041-008x(76)90151-4. [DOI] [PubMed] [Google Scholar]
  5. Ciegler A., Fennell D. I., Sansing G. A., Detroy R. W., Bennett G. A. Mycotoxin-producing strains of Penicillium viridicatum: classification into subgroups. Appl Microbiol. 1973 Sep;26(3):271–278. doi: 10.1128/am.26.3.271-278.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Durley R. C., MacMillan J., Simpson T. J., Glen A. T., Turner W. B. Fungal products. Part XIII. Xanthomegnin, viomellin, rubrosulphin, and viopurpurin, pigments from Aspergillus sulphureus and Aspergillus melleus. J Chem Soc Perkin 1. 1975;(2):163–169. [PubMed] [Google Scholar]
  7. Ito Y., Kawai K., Nozawa Y. Biochemical studies of pigments from the pathogenic fungus, Microsporum cookei. J Biochem. 1973 Oct;74(4):805–810. doi: 10.1093/oxfordjournals.jbchem.a130306. [DOI] [PubMed] [Google Scholar]
  8. Krogh P., Elling F., Hald B., Jylling B., Petersen V. E., Skadhauge E., Svendsen C. K. Experimental avian nephropathy. Changes of renal function and structure induced by ochratoxin A-contaminated feed. Acta Pathol Microbiol Scand A. 1976 Mar;84(2):215–221. [PubMed] [Google Scholar]
  9. Krogh P., Hasselager E., Friis P. Studies on fungal nephrotoxicity. 2. Isolation of two nephrotoxic compounds from Penicillium viridicatum Westling: citrinin and oxalic acid. Acta Pathol Microbiol Scand B Microbiol Immunol. 1970;78(4):401–413. [PubMed] [Google Scholar]
  10. Stack M. E., Brown N. L., Eppley R. M. High pressure liquid chromatographic determination of xanthomegnin in corn. J Assoc Off Anal Chem. 1978 May;61(3):590–592. [PubMed] [Google Scholar]
  11. Stack M. E., Eppley R. M., Dreifuss P. A., Pohland A. E. Isolation and identification of xanthomegnin, viomellein, rubrosulphin, and viopurpurin as metabolites of penicillium viridicatum. Appl Environ Microbiol. 1977 Feb;33(2):351–355. doi: 10.1128/aem.33.2.351-355.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Zimmermann J. L., Carlton W. W., Tuite J., Fennell D. I. Mycotoxic diseases produced in mice by species of the Aspergillus ochraceus group. Food Cosmet Toxicol. 1977 Oct;15(5):411–418. doi: 10.1016/s0015-6264(77)80005-9. [DOI] [PubMed] [Google Scholar]

Articles from Applied and Environmental Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES