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. 1997 Mar;73(857):165–166. doi: 10.1136/pgmj.73.857.165

Drug-induced antisynthetase syndrome.

D R Thickett 1, A B Millar 1
PMCID: PMC2431256  PMID: 9135834

Abstract

We present a case of antisynthetase syndrome whose predominant feature was fibrosing alveolitis and which may have been drug-induced. This responded well to steroids and cyclophosphamide.

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Selected References

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  1. Akoun G., Milleron B., Mayaud C. Les pneumopathies médicamenteuses (cytostatiques exclus). Ann Med Interne (Paris) 1989;140(7):593–596. [PubMed] [Google Scholar]
  2. Love L. A., Leff R. L., Fraser D. D., Targoff I. N., Dalakas M., Plotz P. H., Miller F. W. A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous patient groups. Medicine (Baltimore) 1991 Nov;70(6):360–374. doi: 10.1097/00005792-199111000-00002. [DOI] [PubMed] [Google Scholar]
  3. Marguerie C., Bunn C. C., Beynon H. L., Bernstein R. M., Hughes J. M., So A. K., Walport M. J. Polymyositis, pulmonary fibrosis and autoantibodies to aminoacyl-tRNA synthetase enzymes. Q J Med. 1990 Oct;77(282):1019–1038. doi: 10.1093/qjmed/77.1.1019. [DOI] [PubMed] [Google Scholar]
  4. Mathews M. B., Bernstein R. M. Myositis autoantibody inhibits histidyl-tRNA synthetase: a model for autoimmunity. Nature. 1983 Jul 14;304(5922):177–179. doi: 10.1038/304177a0. [DOI] [PubMed] [Google Scholar]
  5. Mathews M. B., Reichlin M., Hughes G. R., Bernstein R. M. Anti-threonyl-tRNA synthetase, a second myositis-related autoantibody. J Exp Med. 1984 Aug 1;160(2):420–434. doi: 10.1084/jem.160.2.420. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Mitra D., Lovell C. L., Macleod T. I., Tan R. S., Maddison P. J. Clinical and histological features of 'mechanic's hands' in a patient with antibodies to Jo-1--a case report. Clin Exp Dermatol. 1994 Mar;19(2):146–148. doi: 10.1111/j.1365-2230.1994.tb01144.x. [DOI] [PubMed] [Google Scholar]
  7. Stahl N. I., Klippel J. H., Decker J. L. A cutaneous lesion associated with myositis. Ann Intern Med. 1979 Oct;91(4):577–579. doi: 10.7326/0003-4819-91-4-577. [DOI] [PubMed] [Google Scholar]
  8. Yoshida S., Akizuki M., Mimori T., Yamagata H., Inada S., Homma M. The precipitating antibody to an acidic nuclear protein antigen, the Jo-1, in connective tissue diseases. A marker for a subset of polymyositis with interstitial pulmonary fibrosis. Arthritis Rheum. 1983 May;26(5):604–611. doi: 10.1002/art.1780260505. [DOI] [PubMed] [Google Scholar]

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