Abstract
We have reviewed the incidence, type and site of microbiologically proven bacterial infection occurring in 52 patients with the acquired immunodeficiency syndrome (AIDS) who presented to Southmead Hospital, Bristol between 1990 and 1994. A total of 30 (58%) patients had significant bacterial isolates. The majority of infections were community acquired. Overall, more infections were caused by Gram-negative organisms but Gram-positive organisms predominated in bacteraemia. Mycobacterium avium intracellulare (MAI) caused infection in the largest number of patients, followed by Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas sp, and Campylobacter sp. When individual episodes of infection were considered, after MAI, Haemophilus influenzae, Streptococcus pneumoniae and Pseudomonas sp were the organisms most frequently isolated; often these same organisms caused recurrent chest infection. Bacterial infections in AIDS patients are common and although they generally respond well to antimicrobial chemotherapy there is a high recurrence rate, particularly in the respiratory tract, which is the commonest site of infection.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Chaisson R. E. Bacterial pneumonia in patients with human immunodeficiency virus infection. Semin Respir Infect. 1989 Jun;4(2):133–138. [PubMed] [Google Scholar]
- Fish D. N., Danziger L. H. Neglected pathogens: bacterial infections in persons with human immunodeficiency virus infection. A review of the literature (2). Pharmacotherapy. 1993 Nov-Dec;13(6):543–563. [PubMed] [Google Scholar]
- Fraser V. Bacterial infections and AIDS. Mo Med. 1990 Apr;87(4):221–224. [PubMed] [Google Scholar]
- Hickey M. M., Shanson D. C. Septicaemia in patients with and without AIDS at Westminster Hospital, London. J Infect. 1993 Nov;27(3):243–250. doi: 10.1016/0163-4453(93)91981-t. [DOI] [PubMed] [Google Scholar]
- Horsburgh C. R., Jr Mycobacterium avium complex infection in the acquired immunodeficiency syndrome. N Engl J Med. 1991 May 9;324(19):1332–1338. doi: 10.1056/NEJM199105093241906. [DOI] [PubMed] [Google Scholar]
- Krumholz H. M., Sande M. A., Lo B. Community-acquired bacteremia in patients with acquired immunodeficiency syndrome: clinical presentation, bacteriology, and outcome. Am J Med. 1989 Jun;86(6 Pt 2):776–779. doi: 10.1016/0002-9343(89)90472-5. [DOI] [PubMed] [Google Scholar]
- Rolston K. V., Radentz S., Rodriguez S. Bacterial and fungal infections in patients with the acquired immunodeficiency syndrome. Cancer Detect Prev. 1990;14(3):377–381. [PubMed] [Google Scholar]
- Skoutelis A. T., Murphy R. L., MacDonell K. B., VonRoenn J. H., Sterkel C. D., Phair J. P. Indwelling central venous catheter infections in patients with acquired immune deficiency syndrome. J Acquir Immune Defic Syndr. 1990;3(4):335–342. [PubMed] [Google Scholar]