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. 1978 Dec;36(6):794–797. doi: 10.1128/aem.36.6.794-797.1978

Improvement in the sensitivity of DNA polymerase I-deficient Escherichia coli for detecting mutagens and carcinogens.

S Venturini, C Monti-Bragadin
PMCID: PMC243147  PMID: 367267

Abstract

The sensitivity of a polA strain to the antibacterial activity of mutagens and carcinogens may be increased by inserting one or both of the following characteristics, a lexA mutation or the R391 bacterial plasmid. The effects of the lexA mutation and the plasmid appear to be additive. The differential sensitivity of a polA lexA (R391) strain could be adapted as a preliminary screening test for mutagens and potential carcinogens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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