Skip to main content
NCBI home page
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1998 Dec;74(878):733–736. doi: 10.1136/pgmj.74.878.733

Oesophageal subepithelial fibrosis: an extension of oral submucosal fibrosis.

S P Misra 1, V Misra 1, M Dwivedi 1, S C Gupta 1
PMCID: PMC2431640  PMID: 10320888

Abstract

Fifty-five patients with oral submucosal fibrosis and an equal number of patients with no evidence of the disease were studied. All patients underwent upper gastrointestinal endoscopy and any abnormality was noted. Multiple oesophageal biopsies were obtained from the upper end of the oesophagus and from any endoscopically observed abnormality. The histological changes in the two groups were assessed blindly by an experienced histopathologist. Histological abnormalities were noted in the oesophageal mucosa in 2% of controls and 66% of patients with oral submucosal fibrosis (p < 0.0001). In the control group, acanthosis was seen in one patient, while in the patient group atrophy of the squamous epithelium was evident in 52%, hyperkeratosis in 52%, parakeratosis in 30%, dyskeratosis in 14%, acanthosis in 14%, and papillomatosis and mild dysplasia in 2% patients. Subepithelial collagenization was seen in 32 (64%) patients. The oesophageal abnormalities were seen more frequently in patients who had consumed Pan masala, Gutka, betel nut, tobacco or a combination of some or all of these, with or without betel leaf, for > or = 5 years compared to those consuming them for a shorter period of time (91% vs 46%, p < 0.001). It is concluded that oral submucosal fibrosis is not a disease confined to the oral cavity; the oesophagus may also be involved in about two-thirds of patients.

Full text

PDF
733

Images in this article

734Figure 1
on p.734
734Figure 2
on p.734
735Figure 3
on p.735

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Canniff J. P., Harvey W., Harris M. Oral submucous fibrosis: its pathogenesis and management. Br Dent J. 1986 Jun 21;160(12):429–434. doi: 10.1038/sj.bdj.4805876. [DOI] [PubMed] [Google Scholar]
  2. Foster B. A. Oral submucous fibrosis: a cause for concern. Br Dent J. 1986 Jun 7;160(11):378–378. doi: 10.1038/sj.bdj.4805869. [DOI] [PubMed] [Google Scholar]
  3. Jayanthi V., Probert C. S., Sher K. S., Mayberry J. F. Oral submucosal fibrosis--a preventable disease. Gut. 1992 Jan;33(1):4–6. doi: 10.1136/gut.33.1.4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Lemmer J., Shear M. Oral submucous fibrosis. A possible case in a person of Caucasian descent. Br Dent J. 1967 Apr 18;122(8):343–346. [PubMed] [Google Scholar]
  5. Maher R., Ahmed W., Qureshi H., Zuberi S. J., Syed S. Oesophageal changes in oral submucous fibrosis using fibreoptic endoscopy--a pilot study. J Pak Med Assoc. 1991 Dec;41(12):312–313. [PubMed] [Google Scholar]
  6. McGurk M., Craig G. T. Oral submucous fibrosis: two cases of malignant transformation in Asian immigrants to the United Kingdom. Br J Oral Maxillofac Surg. 1984 Feb;22(1):56–64. doi: 10.1016/0266-4356(84)90010-x. [DOI] [PubMed] [Google Scholar]
  7. Misra S. P., Dwivedi M. A mouthguard for endoscopic examination of patients with oral submucous fibrosis and ankylosis of the temporomandibular joint. Endoscopy. 1998 Mar;30(3):S37–S37. doi: 10.1055/s-2007-1001266. [DOI] [PubMed] [Google Scholar]
  8. Pindborg J. J., Kalapessi H. K., Kale S. A., Singh B., Talyerkhan B. N. Frequency of oral leukoplakias and related conditions among 10,000 Bombayites. Preliminary report. J All India Dent Assoc. 1965 Jul;37(7):228–229. [PubMed] [Google Scholar]
  9. Pindborg J. J., Mehta F. S., Gupta P. C., Daftary D. K. Prevalence of oral submucous fibrosis among 50,915 Indian villagers. Br J Cancer. 1968 Dec;22(4):646–654. doi: 10.1038/bjc.1968.76. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Pindborg J. J., Murti P. R., Bhonsle R. B., Gupta P. C., Daftary D. K., Mehta F. S. Oral submucous fibrosis as a precancerous condition. Scand J Dent Res. 1984 Jun;92(3):224–229. doi: 10.1111/j.1600-0722.1984.tb00883.x. [DOI] [PubMed] [Google Scholar]
  11. Pindborg J. J., Sirsat S. M. Oral submucous fibrosis. Oral Surg Oral Med Oral Pathol. 1966 Dec;22(6):764–779. doi: 10.1016/0030-4220(66)90367-7. [DOI] [PubMed] [Google Scholar]
  12. Seedat H. A., van Wyk C. W. Betel chewing and dietary habits of chewers without and with submucous fibrosis and with concomitant oral cancer. S Afr Med J. 1988 Dec 3;74(11):572–575. [PubMed] [Google Scholar]
  13. Seedat H. A., van Wyk C. W. Betel-nut chewing and submucous fibrosis in Durban. S Afr Med J. 1988 Dec 3;74(11):568–571. [PubMed] [Google Scholar]
  14. Shankaran K., Kandarkar S. V., Contractor Q. Q., Kalro R. H., Desai H. G. Ultrastructural changes in esophageal mucosa of chronic tobacco chewers. Indian J Med Res. 1993 Feb;98:15–19. [PubMed] [Google Scholar]
  15. Shiau Y. Y., Kwan H. W. Submucous fibrosis in Taiwan. Oral Surg Oral Med Oral Pathol. 1979 May;47(5):453–457. doi: 10.1016/0030-4220(79)90128-2. [DOI] [PubMed] [Google Scholar]
  16. Zachariah J., Mathew B., Varma N. A., Iqbal A. M., Pindborg J. J. Frequency of oral mucosal lesions among 5000 individuals in Trivandrum, South India. Preliminary report. J Indian Dent Assoc. 1966 Oct-Dec;38(11):290–294. [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES