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. 1979 Jan;37(1):11–13. doi: 10.1128/aem.37.1.11-13.1979

Moniliformin, a metabolite of Fusarium moniliforme NRRL 6322: purification and toxicity.

H R Burmeister, A Ciegler, R F Vesonder
PMCID: PMC243395  PMID: 760629

Abstract

Fusarium moniliforme NRRL 6322 produced about 600 mg of recoverable moniliformin, a mycotoxic metabolite, per kg of corn grit medium. The moniliformin was extracted from the grits with methanol, purified by preparative thin-layer chromatography, and crystallized from ether. The 50% lethal dose for chicken embryos was 2.8 microgram per egg. For 1-day-old chicks dosed with moniliformin by crop intubation and for female and male mice injected intraperitoneally, the 50% lethal doses were 5.4, 20.9, and 29.1 mg per kg of body weight, respectively. The toxin did not cause a reaction on mouse skin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cole R. J., Kirksey J. W., Cutler H. G., Doupnik B. L., Peckham J. C. Toxin from Fusarium moniliforme: Effects on Plants and Animals. Science. 1973 Mar 30;179(4080):1324–1326. doi: 10.1126/science.179.4080.1324. [DOI] [PubMed] [Google Scholar]
  2. Joffe A. Z., Palti J., Arbel-Sherman R. Fusarium moniliforme Sheld. in Israel (Gibberella fujikuroi (Saw.) Wollenw.). Mycopathol Mycol Appl. 1973 Jul 5;50(2):85–107. doi: 10.1007/BF02049949. [DOI] [PubMed] [Google Scholar]
  3. Kellerman T. S., Marasas W. F., Pienaar J. G., Naudé T. W. A mycotoxicosis of equidae caused by Fusarium moniliforme sheldon. A preliminary communication. Onderstepoort J Vet Res. 1972 Dec;39(4):205–208. [PubMed] [Google Scholar]
  4. Kriek N. P., Marasas W. F., Steyn P. S., van Rensburg S. J., Steyn M. Toxicity of a moniliformin-producing strain of Fusarium moniliforme var. subglutinans isolated from maize. Food Cosmet Toxicol. 1977 Dec;15(6):579–587. doi: 10.1016/0015-6264(77)90073-6. [DOI] [PubMed] [Google Scholar]
  5. Rabie C. J., Lübben A., Louw A. I., Rathbone E. B., Steyn P. S., Vleggaar R. Moniliformin, a mycotoxin from Fusarium fusarioides. J Agric Food Chem. 1978 Mar-Apr;26(2):375–379. doi: 10.1021/jf60216a011. [DOI] [PubMed] [Google Scholar]
  6. Sharby T. F., Templeton G. E., Beasley J. N., Stephenson E. L. Toxicity resulting from feeding experimentally molded corn to broiler chicks. Poult Sci. 1973 May;52(3):1007–1014. doi: 10.3382/ps.0521007. [DOI] [PubMed] [Google Scholar]
  7. Springer J. P., Clardy J., Cole R. J., Kirksey J. W., Hill R. K., Carlson M. R., Isidor J. L. Structure and synthesis of moniliformin, a novel cyclobutane microbial toxin. J Am Chem Soc. 1974 Apr 3;96(7):2267–2268. doi: 10.1021/ja00814a055. [DOI] [PubMed] [Google Scholar]
  8. Ueno Y., Ishikawa Y., Nakajima M., Sakai K., Ishii K. Toxicological approaches to the metabolites of Fusaria. I. Screening of toxic strains. Jpn J Exp Med. 1971 Aug;41(4):257–272. [PubMed] [Google Scholar]
  9. Ueno Y., Sato N., Ishii K., Sakai K., Tsunoda H. Biological and chemical detection of trichothecene mycotoxins of Fusarium species. Appl Microbiol. 1973 Apr;25(4):699–704. doi: 10.1128/am.25.4.699-704.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Wilson B. J., Maronpot R. R. Causative fungus agent of leucoencephalomalacia in equine animals. Vet Rec. 1971 May 8;88(19):484–486. doi: 10.1136/vr.88.19.484. [DOI] [PubMed] [Google Scholar]

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