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. 1979 Aug;38(2):191–196. doi: 10.1128/aem.38.2.191-196.1979

Inhibitory effects of carcinogenic mycotoxins on deoxyribonucleic acid-dependent ribonucleic acid polymerase and ribonuclease H.

F Tashiro, K Hiral, Y Ueno
PMCID: PMC243463  PMID: 117749

Abstract

Fourteen mycotoxins were tested for inhibitory effects on ribonucleic acid polymerase of rat liver and Escherichia coli and nuclear ribonuclease H of rat liver and Tetrahymena pyriformis. These enzymes were strongly inhibited by (-)-luteoskyrin, (+)-rugulosin, patulin, and PR toxin.

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Selected References

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  1. Akinrimisi E. O., Benecke B. J., Seifart K. H. Inhibition of rat-liver RNA polymerase in vitro by aflatoxin B1 in the presence of microsomal fraction. Eur J Biochem. 1974 Mar 1;42(2):333–339. doi: 10.1111/j.1432-1033.1974.tb03344.x. [DOI] [PubMed] [Google Scholar]
  2. Burgess R. R. A new method for the large scale purification of Escherichia coli deoxyribonucleic acid-dependent ribonucleic acid polymerase. J Biol Chem. 1969 Nov 25;244(22):6160–6167. [PubMed] [Google Scholar]
  3. Ciegler A. Mycotoxins: occurrence, chemistry, biological activity. Lloydia. 1975 Jan-Feb;38(1):21–35. [PubMed] [Google Scholar]
  4. Enomoto M., Saito M. Carcinogens produced by fungi. Annu Rev Microbiol. 1972;26:279–312. doi: 10.1146/annurev.mi.26.100172.001431. [DOI] [PubMed] [Google Scholar]
  5. Hausen P., Stein H. Ribonuclease H. An enzyme degrading the RNA moiety of DNA-RNA hybrids. Eur J Biochem. 1970 Jun;14(2):278–283. doi: 10.1111/j.1432-1033.1970.tb00287.x. [DOI] [PubMed] [Google Scholar]
  6. Ishii K., Sawano M., Ueno Y., Tsunoda H. Distribution of zearalenone-producing Fusarium species in Japan. Appl Microbiol. 1974 Apr;27(4):625–628. doi: 10.1128/am.27.4.625-628.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ishii K., Ueno Y. Production of the hepatotoxic chlorine-containing peptide by Penicillium islandicum Sopp. Appl Microbiol. 1973 Sep;26(3):359–363. doi: 10.1128/am.26.3.359-363.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Miller H. I., Riggs A. D., Gill G. N. Ribonuclease H (hybrid) in Escherichia coli. Identification and characterization. J Biol Chem. 1973 Apr 10;248(7):2621–2624. [PubMed] [Google Scholar]
  9. Moulé Y., Jemmali M., Rousseau N. Mechanism of the inhibition of transcription by PR toxin, a mycotoxin from Penicillium roqueforti. Chem Biol Interact. 1976 Aug;14(3-4):207–216. doi: 10.1016/0009-2797(76)90101-0. [DOI] [PubMed] [Google Scholar]
  10. Roeder R. G., Rutter W. J. Multiple forms of DNA-dependent RNA polymerase in eukaryotic organisms. Nature. 1969 Oct 18;224(5216):234–237. doi: 10.1038/224234a0. [DOI] [PubMed] [Google Scholar]
  11. Ruet A., Sentenac A., Simon E. J., Bouhet J. C., Fromageot P. Interaction of ribonucleic acid polymerase from Escherichia coli with deoxyribonucleic acid. Inhibition of ribonucleic acid synthesis by interaction of luteoskyrin with the transcription complex. Biochemistry. 1973 Jun 5;12(12):2318–2324. doi: 10.1021/bi00736a021. [DOI] [PubMed] [Google Scholar]
  12. Shinohara Y., Arai M., Hirao K., Sugihara S., Nakanishi K. Combination effect of citrinin and other chemicals on rat kidney tumorigenesis. Gan. 1976 Apr;67(2):147–155. [PubMed] [Google Scholar]
  13. Tashiro F., Mita T., Higashinakagawa T. Multiple forms of nuclear ribonuclease H from Tetrahymena pyriformis. Eur J Biochem. 1976 May 17;65(1):123–130. doi: 10.1111/j.1432-1033.1976.tb10396.x. [DOI] [PubMed] [Google Scholar]
  14. Tashiro F., Ueno Y. Ribonuclease H from rat liver. I. Partial purification and characterization of nuclear ribonuclease H1. J Biochem. 1978 Aug;84(2):385–393. doi: 10.1093/oxfordjournals.jbchem.a132139. [DOI] [PubMed] [Google Scholar]
  15. Ueno Y., Hosoya M., Ishikawa Y. Inhibitory effects of mycotoxins on the protein synthesis in rabbit reticulocytes. J Biochem. 1969 Sep;66(3):419–422. doi: 10.1093/oxfordjournals.jbchem.a129163. [DOI] [PubMed] [Google Scholar]
  16. Ueno Y., Ishikawa I. Production of luteoskyrin, a hepatotoxic pigment, by Penicillium islandicum Sopp. Appl Microbiol. 1969 Sep;18(3):406–409. doi: 10.1128/am.18.3.406-409.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Ueno Y., Kubota K. DNA-attacking ability of carcinogenic mycotoxins in recombination-deficient mutant cells of Bacillus subtilis. Cancer Res. 1976 Feb;36(2 Pt 1):445–451. [PubMed] [Google Scholar]
  18. Ueno Y., Kubota K., Ito T., Nakamura Y. Mutagenicity of carcinogenic mycotoxins in Salmonella typhimurium. Cancer Res. 1978 Mar;38(3):536–542. [PubMed] [Google Scholar]
  19. Ueno Y., Matsumoto H., Ishi K., Kukita K. I. Inhibitory effects of mycotoxins on Na+-dependent transport of glycine in rabbit reticulocytes. Biochem Pharmacol. 1976 Sep 15;25(18):2091–2095. doi: 10.1016/0006-2952(76)90435-4. [DOI] [PubMed] [Google Scholar]
  20. Ueno Y., Ueno I., Amakai K., Ishikawa Y., Tsunoda H. Toxicological approaches to the metabolites of Fusaria. II. Isolation of fusarenon-X from the culture filtrate of Fusarium nivale Fn 2B. Jpn J Exp Med. 1971 Dec;41(6):507–519. [PubMed] [Google Scholar]
  21. Ueno Y., Ueno I., Ito K., Tatsuno T. Impairments of RNA synthesis in Ehrlich ascites tumour by luteoskyrin, a hepatotoxic pigment of Penicillium islandicum Sopp. Experientia. 1967 Dec 15;23(12):1001–1002. doi: 10.1007/BF02136409. [DOI] [PubMed] [Google Scholar]
  22. Ueno Y., Ueno I., Sato N., Iitoi Y., Saito M. Toxicological approach to (+) rugulosin, an anthraquinoid mycotoxin of Penicillium rugulosum Thom. Jpn J Exp Med. 1971 Jun;41(3):177–188. [PubMed] [Google Scholar]
  23. Ueno Y., Ueno I., Tatsuno T., Ookubo K., Tsunoda H. Fusareon-X, a toxic principle of Fusarium nivale--culture filtrate. Experientia. 1969 Oct 15;25(10):1062–1062. doi: 10.1007/BF01901430. [DOI] [PubMed] [Google Scholar]
  24. Umeda M., Ohtsubo K., Saito M., Sekita S., Yoshihira K. Cytotoxicity of new cytochalasans from Chaetomium globosum. Experientia. 1975 Apr 15;31(4):435–438. doi: 10.1007/BF02026363. [DOI] [PubMed] [Google Scholar]
  25. Uraguchi K., Saito M., Noguchi Y., Takahashi K., Enomoto M. Chronic toxicity and carcinogenicity in mice of the purified mycotoxins, luteoskyrin and cyclochlorotine. Food Cosmet Toxicol. 1972 Apr;10(2):193–207. doi: 10.1016/s0015-6264(72)80197-4. [DOI] [PubMed] [Google Scholar]
  26. Weinmann R., Raskas H. J., Roeder R. G. Role of DNA-dependent RNA polymerases II and III in transcription of the adenovirus genome late in productive infection. Proc Natl Acad Sci U S A. 1974 Sep;71(9):3426–3439. doi: 10.1073/pnas.71.9.3426. [DOI] [PMC free article] [PubMed] [Google Scholar]

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