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. 1981 Mar;41(3):729–736. doi: 10.1128/aem.41.3.729-736.1981

Mycophenolic Acid Production by Penicillium brevicompactum on Solid Media

C D Bartman 1, D L Doerfler 1, B A Bird 1, A T Remaley 1, J N Peace 1, I M Campbell 1
PMCID: PMC243768  PMID: 16345733

Abstract

When grown on Czapek-Dox agar, Penicillium brevicompactum produced mycophenolic acid after a vegetative mycelium had been formed and as aerial hyphae were developing. Nutrients were still plenteous in the agar when the synthesis began. If aerial hyphal development was prevented by placing a dialysis membrane over the growing fungus, no mycophenolic acid was produced. When the dialysis membrane was peeled back and, as a consequence, production of aerial hyphae began, mycophenolic acid biosynthesis was observed. We concluded that mycophenolic acid was produced only by P. brevicompactum colonies that possessed an aerial mycelium.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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