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. 1981 Apr;41(4):942–949. doi: 10.1128/aem.41.4.942-949.1981

Metabolism of 4-Chloronitrobenzene by the Yeast Rhodosporidium sp

Michael D Corbett 1, Bernadette R Corbett 1
PMCID: PMC243838  PMID: 16345757

Abstract

The yeast Rhodosporidium sp. metabolized 4-chloronitrobenzene by a reductive pathway to give 4-chloroacetanilide and 4-chloro-2-hydroxyacetanilide as the major final metabolites. The intermediate production of 4-chloronitrosobenzene, 4-chlorophenylhydroxylamine, and 4-chloroaniline was demonstrated by high-pressure liquid chromatography. Additional studies with selected metabolites established that the metabolite 4-chloro-2-hydroxyacetanilide was produced by an initial Bamberger rearrangement of the hydroxylamine metabolite, followed by acetylation. Direct C hydroxylation of the aromatic ring was not observed in this species. No hydroxamic acid production was detected, even though significant concentrations of the nitroso and hydroxylamine precursors to this functional group were observed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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