Skip to main content
NCBI home page
Transactions of the American Clinical and Climatological Association logoLink to Transactions of the American Clinical and Climatological Association
. 1973;84:166–182.

A reappraisal of the concept of an abnormality of glutamine metabolism in primary gout.

J B Wyngaarden, O Sperling, F Starmer
PMCID: PMC2441285  PMID: 4729251

Full text

PDF
166

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENEDICT J. D., ROCHE M., YU T. F., BIEN E. J., GUTMAN A. B., STETTEN D., Jr Incorporation of glycine nitrogen into uric acid in normal and gouty man. Metabolism. 1952 Jan;1(1):3–12. [PubMed] [Google Scholar]
  2. BENEDICT J. D., YU T. F., BIEN E. J., GUTMAN A. B., STETTEN D., Jr A further study of the utilization of dietary glycine nitrogen for uric acid synthesis in gout. J Clin Invest. 1953 Aug;32(8):775–777. doi: 10.1172/JCI102791. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BRANDENBERGER H. The oxidation of uric acid to oxonic acid (allantoxanic acid) and its application in tracer studies of uric acid biosynthesis. Biochim Biophys Acta. 1954 Sep;15(1):108–116. doi: 10.1016/0006-3002(54)90099-2. [DOI] [PubMed] [Google Scholar]
  4. Becker M. A., Meyer L. J., Wood A. W., Seegmiller J. E. Purine overproduction in man associated with increased phosphoribosylpyrophosphate synthetase activity. Science. 1973 Mar 16;179(4078):1123–1126. doi: 10.1126/science.179.4078.1123. [DOI] [PubMed] [Google Scholar]
  5. CASKEY C. T., ASHTON D. M., WYNGAARDEN J. B. THE ENZYMOLOGY OF FEEDBACK INHIBITION OF GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE BY PURINE RIBONUCLEOTIDES. J Biol Chem. 1964 Aug;239:2570–2579. [PubMed] [Google Scholar]
  6. Emmerson B. T., Wyngaarden J. B. Purine metabolism in heterozygous carriers of hypoxanthine-guanine phosphoribosyltransferase deficiency. Science. 1969 Dec 19;166(3912):1533–1535. doi: 10.1126/science.166.3912.1533. [DOI] [PubMed] [Google Scholar]
  7. Fox I. H., Kelley W. N. Phosphoribosylpyrophosphate in man: biochemical and clinical significance. Ann Intern Med. 1971 Mar;74(3):424–433. doi: 10.7326/0003-4819-74-3-424. [DOI] [PubMed] [Google Scholar]
  8. Fox I. H., Wyngaarden J. B., Kelley W. N. Depletion of erythrocyte phosphoribosylpyrophosphate in man. N Engl J Med. 1970 Nov 26;283(22):1177–1182. doi: 10.1056/NEJM197011262832201. [DOI] [PubMed] [Google Scholar]
  9. GOLDTHWAIT D. A., GREENBERG G. R., PEABODY R. A. On the mechanism of synthesis of glycinamide ribotide and its formyl derivative. J Biol Chem. 1956 Aug;221(2):569–577. [PubMed] [Google Scholar]
  10. GUTMAN A. B., YUE T. F. AN ABNORMALITY OF GLUTAMINE METABOLISM IN PRIMARY GOUT. Am J Med. 1963 Dec;35:820–831. doi: 10.1016/0002-9343(63)90244-4. [DOI] [PubMed] [Google Scholar]
  11. GUTMAN A. B., YUE T. F. URINARY AMMONIUM EXCRETION IN PRIMARY GOUT. J Clin Invest. 1965 Sep;44:1474–1481. doi: 10.1172/JCI105254. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. GUTMAN A. B., YU F. T., ADLER M., JAVITT N. B. Intramolecular distribution of uric acid-N15 after administration of glycine-N15 and ammonium-N15 chloride to goury and non-goury subjects. J Clin Invest. 1962 Mar;41:623–636. doi: 10.1172/JCI104518. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. GUTMAN A. B., YU T. F., BLACK H., YALOW R. S., BERSON S. A. Incorporation of glycine-1-C14, glycine-2-C14 and glycine-N15 into uric acid in normal and gouty subjects. Am J Med. 1958 Dec;25(6):917–932. doi: 10.1016/0002-9343(58)90063-9. [DOI] [PubMed] [Google Scholar]
  14. GUTMAN A. B., YU T. F. Renal function in gout; with a commentary on the renal regulation of urate excretion, and the role of the kidney in the pathogenesis of gout. Am J Med. 1957 Oct;23(4):600–622. doi: 10.1016/0002-9343(57)90231-0. [DOI] [PubMed] [Google Scholar]
  15. HARTMAN S. C., BUCHANAN J. M. Biosynthesis of the purines. XXI. 5-Phosphoribosylpyrophosphate amidotransferase. J Biol Chem. 1958 Aug;233(2):451–455. [PubMed] [Google Scholar]
  16. HENDERSON J. F., KHOO M. K. SYNTHESIS OF 5-PHOSPHORIBOSYL 1-PYROPHOSPHATE FROM GLUCOSE IN EHRLICH ASCITES TUMOR CELLS IN VITRO. J Biol Chem. 1965 Jun;240:2349–2357. [PubMed] [Google Scholar]
  17. HOWELL R. R., ASHTON D. M., WYNGAARDEN J. B. Glucose-6-phosphatase deficiency glycogen storage disease. Studies on the interrelationships of carbohydrate, lipid, and purine abnormalities. Pediatrics. 1962 Apr;29:553–565. [PubMed] [Google Scholar]
  18. HOWELL R. R., SPEAS M., WYNGAARDEN J. B. A quantitative study of recycling of isotope from glycine-1-C14, alpha-N15 into various subunits of the uric acid molecule in a normal subject. J Clin Invest. 1961 Nov;40:2076–2082. doi: 10.1172/JCI104433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Hershko A., Hershko C., Mager J. Increased formation of 5-phosphoriboxyl-1-pyrophosphate in red blood cells of some gouty patients. Isr J Med Sci. 1968 Sep-Oct;4(5):939–944. [PubMed] [Google Scholar]
  20. Holmes E. W., McDonald J. A., McCord J. M., Wyngaarden J. B., Kelley W. N. Human glutamine phosphoribosylpyrophosphate amidotransferase. Kinetic and regulatory properties. J Biol Chem. 1973 Jan 10;248(1):144–150. [PubMed] [Google Scholar]
  21. JONES O. W., Jr, ASHTON D. M., WYNGAARDEN J. B. Accelerated turnover of phosphoribosylpyrophosphate, a purine nucleotide precursor, in certain gouty subjects. J Clin Invest. 1962 Sep;41:1805–1815. doi: 10.1172/JCI104638. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. KAPLAN D., BERNSTEIN D., WALLACE S. L., HALBERSTAM D. SERUM AND URINARY AMINO ACIDS IN NORMOURICEMIC AND HYPERURICEMIC SUBJECTS. Ann Intern Med. 1965 Apr;62:658–666. doi: 10.7326/0003-4819-62-4-658. [DOI] [PubMed] [Google Scholar]
  23. KENNAN A. L. Glutamine synthesis in rats with diabetic acidosis. Endocrinology. 1962 Aug;71:203–208. doi: 10.1210/endo-71-2-203. [DOI] [PubMed] [Google Scholar]
  24. Kelley W. N., Fox I. H., Wyngaarden J. B. Regulation of purine biosynthesis in cultured human cells. I. Effects of orotic acid. Biochim Biophys Acta. 1970 Sep 22;215(3):512–516. doi: 10.1016/0304-4165(70)90101-7. [DOI] [PubMed] [Google Scholar]
  25. Kelley W. N., Greene M. L., Rosenbloom F. M., Henderson J. F., Seegmiller J. E. Hypoxanthine-guanine phosphoribosyltransferase deficiency in gout. Ann Intern Med. 1969 Jan;70(1):155–206. doi: 10.7326/0003-4819-70-1-155. [DOI] [PubMed] [Google Scholar]
  26. Kelley W. N., Rosenbloom F. M., Henderson J. F., Seegmiller J. E. A specific enzyme defect in gout associated with overproduction of uric acid. Proc Natl Acad Sci U S A. 1967 Jun;57(6):1735–1739. doi: 10.1073/pnas.57.6.1735. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Kelley W. N., Rosenbloom F. M., Seegmiller J. E., Howell R. R. Excessive production of uric acid in type I glycogen storage disease. J Pediatr. 1968 Apr;72(4):488–496. doi: 10.1016/s0022-3476(68)80339-7. [DOI] [PubMed] [Google Scholar]
  28. Kelley W. N., Rosenbloom F. M., Seegmiller J. E. The effects of azathioprine (imuran) on purine synthesis in clinical disorders of purine metabolism. J Clin Invest. 1967 Sep;46(9):1518–1529. doi: 10.1172/JCI105643. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. LESCH M., NYHAN W. L. A FAMILIAL DISORDER OF URIC ACID METABOLISM AND CENTRAL NERVOUS SYSTEM FUNCTION. Am J Med. 1964 Apr;36:561–570. doi: 10.1016/0002-9343(64)90104-4. [DOI] [PubMed] [Google Scholar]
  30. LEVENBERG B., HARTMAN S. C., BUCHANAN J. M. Biosynthesis of the purines. X. Further studies in vitro on the metabolic origin of nitrogen atoms 1 and 3 of the purine ring. J Biol Chem. 1956 May;220(1):379–390. [PubMed] [Google Scholar]
  31. MOLDAVE K., MEISTER A. Enzymic acylation of glutamine by phenylacetic acid. Biochim Biophys Acta. 1957 Jun;24(3):654–655. doi: 10.1016/0006-3002(57)90269-x. [DOI] [PubMed] [Google Scholar]
  32. MOLDAVE K., MEISTER A. Participation: of phenylacetyl-adenylate in the enzymic synthesis of phenylacetylglutamine. Biochim Biophys Acta. 1957 Aug;25(2):434–435. doi: 10.1016/0006-3002(57)90500-0. [DOI] [PubMed] [Google Scholar]
  33. OWEN E. E., ROBINSON R. R. Amino acid extraction and ammonia metabolism by the human kidney during the prolonged administration of ammonium chloride. J Clin Invest. 1963 Feb;42:263–276. doi: 10.1172/JCI104713. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. PITTS R. F., PILKINGTON L. A., DEHAAS J. C. N15 TRACER STUDIES ON THE ORIGIN OF URINARY AMMONIA IN THE ACIDOTIC DOG, WITH NOTES ON THE ENZYMATIC SYNTHESIS OF LABELED CLUTAMIC ACID AND GLUTAMINES. J Clin Invest. 1965 May;44:731–745. doi: 10.1172/JCI105186. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Pollak V. E., Mattenheimer H. Glutaminase activity in the kidney in gout. J Lab Clin Med. 1965 Oct;66(4):564–570. [PubMed] [Google Scholar]
  36. SEEGMILLER J. E., GRAYZEL A. I., LASTER L., LIDDLE L. Uric acid production in gout. J Clin Invest. 1961 Jul;40:1304–1314. doi: 10.1172/JCI104360. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. SEGAL S., WYNGAARDEN J. B. Plasma glutamine and oxypurine content in patients with gout. Proc Soc Exp Biol Med. 1955 Mar;88(3):342–345. doi: 10.3181/00379727-88-21583. [DOI] [PubMed] [Google Scholar]
  38. SONNE J. C., LIN I., BUCHANAN J. M. Biosynthesis of the purines. IX. Precursors of the nitrogen atoms of the purine ring. J Biol Chem. 1956 May;220(1):369–378. [PubMed] [Google Scholar]
  39. SONNE J. C., LIN I., BUCHANAN J. M. Biosynthesis of the purines. IX. Precursors of the nitrogen atoms of the purine ring. J Biol Chem. 1956 May;220(1):369–378. [PubMed] [Google Scholar]
  40. STEIN W. H. A chromatographic investigation of the amino acid constituents of normal urine. J Biol Chem. 1953 Mar;201(1):45–58. [PubMed] [Google Scholar]
  41. Seegmiller J. E., Klinenberg J. R., Miller J., Watts R. W. Suppression of glycine-15N incorporation into urinary uric acid by adenine-8-13C in normal and gouty subjects. J Clin Invest. 1968 May;47(5):1193–1203. doi: 10.1172/JCI105808. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Sperling O., Boer P., Persky-Brosh S., Kanarek E., De Vries A. Altered kinetic property of erythrocyte phosphoribosylpsyrophosphate synthetase in excessive purine production. Rev Eur Etud Clin Biol. 1972 Aug-Sep;17(7):703–706. [PubMed] [Google Scholar]
  43. Sperling O., Eilam G., Sara-Persky-Brosh, De Vries A. Accelerated erythrocyte 5-phosphoribosyl-1-pyrophosphate synthesis. A familial abnormality associated with excessive uric acid production and gout. Biochem Med. 1972 Aug;6(4):310–316. doi: 10.1016/0006-2944(72)90017-8. [DOI] [PubMed] [Google Scholar]
  44. Sperling O., Frank M., Ophir R., Liberman U. A., Adam A., de Vries A. Partial deficiency of hypoxanthine-guanine phosphoribosyltransferase associated with gout and uric acid lithiasis. Rev Eur Etud Clin Biol. 1970 Nov;15(9):942–947. [PubMed] [Google Scholar]
  45. Sperling O., Ophir R., de Vries A. Purine base incorporation into erythrocyte nucleotides and erythrocyte phosphoribosyltransferase activity in primary gout. Rev Eur Etud Clin Biol. 1971 Feb;16(2):147–151. [PubMed] [Google Scholar]
  46. Stone W. J., Balagura S., Pitts R. F. Diffusion equilibrium for ammonia in the kidney of the acidotic dog. J Clin Invest. 1967 Oct;46(10):1603–1608. doi: 10.1172/JCI105652. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Williamson D. H., Lopes-Vieira O., Walker B. Concentrations of free glucogenic amino acids in livers of rats subjected to various metabolic stresses. Biochem J. 1967 Aug;104(2):497–502. doi: 10.1042/bj1040497. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Yü T. F., Adler M., Bobrow E., Gutman A. B. Plasma and urinary amino acids in primary gout, with special reference to glutamine. J Clin Invest. 1969 May;48(5):885–894. doi: 10.1172/JCI106047. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Zilversmit D. B., Entenman C., Fishler M. C. ON THE CALCULATION OF "TURNOVER TIME" AND "TURNOVER RATE" FROM EXPERIMENTS INVOLVING THE USE OF LABELING AGENTS. J Gen Physiol. 1943 Jan 20;26(3):325–331. doi: 10.1085/jgp.26.3.325. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Transactions of the American Clinical and Climatological Association are provided here courtesy of American Clinical and Climatological Association

RESOURCES