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American Journal of Alzheimer's Disease and Other Dementias logoLink to American Journal of Alzheimer's Disease and Other Dementias
. 2007 Dec;22(6):474–488. doi: 10.1177/1533317507308779

Distinct MRI Atrophy Patterns in Autopsy-Proven Alzheimer's Disease and Frontotemporal Lobar Degeneration

GD Rabinovici 1, WW Seeley 2, EJ Kim 3, ML Gorno-Tempini 4, K Rascovsky 5, TA Pagliaro 6, SC Allison 7, C Halabi 8, JH Kramer 9, JK Johnson 10, MW Weiner 11, MS Forman 12, JQ Trojanowski 13, SJ DeArmond 14, BL Miller 15, HJ Rosen 16
PMCID: PMC2443731  NIHMSID: NIHMS48396  PMID: 18166607

Abstract

To better define the anatomic distinctions between Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD), we retrospectively applied voxel-based morphometry to the earliest magnetic resonance imaging scans of autopsy-proven AD (N = 11), FTLD (N = 18), and controls (N = 40). Compared with controls, AD patients showed gray matter reductions in posterior temporoparietal and occipital cortex; FTLD patients showed atrophy in medial prefrontal and medial temporal cortex, insula, hippocampus, and amygdala; and patients with both disorders showed atrophy in dorsolateral and orbital prefrontal cortex and lateral temporal cortex (P FWE-corr < .05). Compared with FTLD, AD patients had decreased gray matter in posterior parietal and occipital cortex, whereas FTLD patients had selective atrophy in anterior cingulate, frontal insula, subcallosal gyrus, and striatum (P < .001, uncorrected). These findings suggest that AD and FTLD are anatomically distinct, with degeneration of a posterior parietal network in AD and degeneration of a paralimbic fronto-insular-striatal network in FTLD.

Keywords: Alzheimer's disease, frontotemporal lobar degeneration, autopsy, magnetic resonance imaging, voxel-based morphometry

Full Text

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Contributor Information

G.D. Rabinovici, Memory and Aging Center, University of California, San Francisco, California, Departments of Neurology, University of California, San Francisco, California, grabinovici@memory.ucsf.edu .

W.W. Seeley, Memory and Aging Center, University of California, San Francisco, California, Departments of Neurology, University of California, San Francisco, California.

E.J. Kim, Memory and Aging Center, University of California, San Francisco, California, Departments of Neurology, University of California, San Francisco, California.

M.L. Gorno-Tempini, Memory and Aging Center, University of California, San Francisco, California, Departments of Neurology, University of California, San Francisco, California.

K. Rascovsky, Memory and Aging Center, University of California, San Francisco, California.

T.A. Pagliaro, Memory and Aging Center, University of California, San Francisco, California.

S.C. Allison, Memory and Aging Center, University of California, San Francisco, California.

C. Halabi, Memory and Aging Center, University of California, San Francisco, California.

J.H. Kramer, Memory and Aging Center, University of California, San Francisco, California, Departments of Neurology, University of California, San Francisco, California.

J.K. Johnson, Memory and Aging Center, University of California, San Francisco, California, Departments of Neurology, University of California, San Francisco, California.

M.W. Weiner, Department of Radiology, University of California, San Francisoc, California, Magnetic Resonance Imaging Unit San Francisco Veterans Affairs Hospital, San Francisco, California.

M.S. Forman, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, Institute on Aging Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

J.Q. Trojanowski, Institute on Aging Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

S.J. DeArmond, Department of Pathology University of California, San Francisco, California.

B.L. Miller, Memory and Aging Center, University of California, San Francisco, California, Departments of Neurology, University of California, San Francisco, California.

H.J. Rosen, Memory and Aging Center, University of California, San Francisco, California, Departments of Neurology, University of California, San Francisco, California.

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