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. 2005 Jun;6(4):204–216. doi: 10.1002/cfg.473

The Cadherin Superfamily in Anopheles gambiae: a Comparative Study With Drosophila melanogaster

Catarina Moita 1,✉, Sérgio Simões 1,3, Luís F Moita 2, António Jacinto 1,3, Pedro Fernandes 1
PMCID: PMC2447487  PMID: 18629193

Abstract

The cadherin superfamily is a diverse and multifunctional group of proteins with extensive representation across genomes of phylogenetically distant species that is involved in cell–cell communication and adhesion. The mosquito Anopheles gambiae is an emerging model organism for the study of innate immunity and host–pathogen interactions, where the malaria parasite induces a profound rearrangement of the actin cytoskeleton at critical stages of infection. We have used bioinformatics tools to retrieve present sequence knowledge about the complete repertoire of cadherins in A. gambiae and compared it to that of the fruit fly, Drosophila melanogaster. In A. gambiae, we have identified 43 genes coding for cadherin extracellular domains that were re-annotated to 38 genes and represent an expansion of this gene family in comparison to other invertebrate organisms. The majority of Drosophila cadherins show a 1 : 1 Anopheles orthologue, but we have observed a remarkable expansion in some groups in A. gambiae, such as N-cadherins, that were recently shown to have a role in the olfactory system of the fruit fly. In vivo dsRNA silencing of overrepresented genes in A. gambiae and other genes showing expression at critical tissues for parasite infection will likely advance our understanding of the problems of host preference and host–pathogen interactions in this mosquito species.

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Selected References

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