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. 2005 Oct-Dec;6(7-8):345–356. doi: 10.1002/cfg.492

In Silico Analysis for Transcription Factors With Zn(II)2C6 Binuclear Cluster DNA-Binding Domains in Candida albicans

Sergi Maicas 1, Inmaculada Moreno 2, Almudena Nieto 2, Micaela Gómez 1, Rafael Sentandreu 2, Eulogio Valentín 2,✉
PMCID: PMC2447501  PMID: 18629206

Abstract

A total of 6047 open reading frames in the Candida albicans genome were screened for Zn(II)2C6-type zinc cluster proteins (or binuclear cluster proteins) involved in DNA recognition. These fungal proteins are transcription regulators of genes involved in a wide range of cellular processes, including metabolism of different compounds such as sugars or amino acids, as well as multi-drug resistance, control of meiosis, cell wall architecture, etc. The selection criteria used in the sequence analysis were the presence of the CysX2CysX6CysX5-16CysX2CysX6-8Cys motif and a putative nuclear localization signal. Using this approach, 70 putative Zn(II)2C6 transcription factors have been found in the genome of C. albicans.

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Selected References

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