Abstract
The incidence of primary cutaneous malignant melanoma is increasing in the developed countries. Cutaneous malignant melanomas diagnosed in our Department over a period of fifty years from 1930 to 1980 were examined to see if there was any change in their histological features. In 1930 and 1955, over 90% of malignant melanomas presented as tumours infiltrating deep into the subepithelial tissue. By 1980, 55% of tumours presented with deeply infiltrating lesions and only 20% occurred at a stage where adequate local excision could provide hope of a cure. There is thus a need for greater awareness among the medical profession and the public if we hope to be able to treat malignant melanomas at an early stage.
Full text
PDF





Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Breslow A. Prognosis in cutaneous melanoma: tumor thickness as a guide to treatment. Pathol Annu. 1980;15(Pt 1):1–22. [PubMed] [Google Scholar]
- Breslow A. Prognostic factors in the treatment of cutaneous melanoma. J Cutan Pathol. 1979 Jun;6(3):208–212. doi: 10.1111/j.1600-0560.1979.tb01125.x. [DOI] [PubMed] [Google Scholar]
- Clark W. H., Jr, From L., Bernardino E. A., Mihm M. C. The histogenesis and biologic behavior of primary human malignant melanomas of the skin. Cancer Res. 1969 Mar;29(3):705–727. [PubMed] [Google Scholar]
- Davis N. C. Melanoma: issues of importance to the clinician. Br J Hosp Med. 1985 Mar;33(3):166–170. [PubMed] [Google Scholar]
- Gordon L. G., Lowry W. S. The incidence and pathogenesis of invasive cutaneous malignant melanoma in Northern Ireland. Br J Cancer. 1986 Jan;53(1):75–80. doi: 10.1038/bjc.1986.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Little J. H., Holt J., Davis N. Changing epidemiology of malignant melanoma in Queensland. Med J Aust. 1980 Jan 26;1(2):66–69. [PubMed] [Google Scholar]
- MacKie R. M., Hunter J. A. Cutaneous malignant melanoma in Scotland. Br J Cancer. 1982 Jul;46(1):75–80. doi: 10.1038/bjc.1982.167. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McGovern V. J., Mihm M. C., Jr, Bailly C., Booth J. C., Clark W. H., Jr, Cochran A. J., Hardy E. G., Hicks J. D., Levene A., Lewis M. G. The classification of malignant melanoma and its histologic reporting. Cancer. 1973 Dec;32(6):1446–1457. doi: 10.1002/1097-0142(197312)32:6<1446::aid-cncr2820320623>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
- Pondes S., Hunter J. A., White H., McIntyre M. A., Prescott R. J. Cutaneous malignant melanoma in south-east Scotland. Q J Med. 1981;50(197):103–121. [PubMed] [Google Scholar]
- Schmoeckel C., Braun-Falco O. Prognostic index in malignant melanoma. Arch Dermatol. 1978 Jun;114(6):871–873. [PubMed] [Google Scholar]
